桂红胶囊提取工艺研究

Study on Extracting Process of Guihong Capsule

目的：研究桂红胶囊的提取工艺,确定最佳的提取工艺条件。方法：以挥发油、红景天苷、浸膏率、乙醇可溶物的提取量为指标,采用正交试验法优选提取方法和参数。结果：将桂枝粉碎成粗粉,与罗勒加8倍量水,共同浸泡2 h,采用水蒸气蒸馏法提取挥发油5 h,提取挥发油后的药液另器保存;将提取挥发油后的药渣加水煎煮两次,第一次加8倍量水,第二次加6倍量水,每次煎煮2 h;提取液与提取挥发油后的药液合并,浓缩至相对密度为1.05-1.08（55℃）,加乙醇使其含醇量为60%,静置8 h,滤过,滤液与银杏叶提取液合并。结论：确定的工艺合理、稳定,重现性好,有效成分提出率高,为桂红胶囊的生产提供了依据。

Objective：To optimize the extracting processes in Guihong capsule manufacturing and to determine the best conditions for the extraction process. Methods：Optimized extraction processes were investigated by using orthogonal design. The essential oil,Rhodiola glucoside,extraction rate,alcohol extracts were used as indicators in the investigation. Results：Taking 8 times water as solvent,cassia twig were milled into coarse powder and soaked for 2 hours after mixing with basil. The essential oil was extracted by means of steam distillation for 5 hours. After extracting volatile oil,the drug soup was preserved in another container.Dregs of decoction were extracted in sequence twice with 8 and 6 times volume of water,and 2 hours per time. The extract and drug soup which has extracted volatile oil were mixed,condensing to the relative density of 1.05-1.08（55 ℃）. Ethanol was added to make the alcohol content 60%,for 8 hours,filtrated.The filtrate was mixed with ginkgo biloba extract. Conclusion：The optimized processes are rational,stable,repeatable and with high yield of active constituents,which supply references for the production of Guihong capsule.