摘要
银屑病是一种常见的红斑、鳞屑性皮肤病,目前认为该病是遗传因素与环境因素等多种因素相互作用的结果。近年来,研究者利用全基因组关联分析的方法发现了新的银屑病易患基因——晚期角质化包膜蛋白(LCE),且在一些人群中已得到证实。该文主要介绍LCE基因与银屑病相关性的研究进展,简要概括其他银屑病易患基因位点及其发病过程中存在的基因-基因间的交互作用及银屑病与皮肤屏障功能损伤之间的相关性。
Psoriasis is a common erythematous lepidic skin disease. At present,it is considered as a result of the interaction between heredity,environment and so on. In recent years,a new psoriasis susceptibility genelate-cornified envelope（ LCE） was discovered by genome wide association study（ GWAS）,which was confirmed existence in some people. Here is to summarize the advances in research of the association between LCE genes and psoriasis,the interaction between LCE3C / LCE3B deletion and HLA-Cw06 and the association between the injury of skin barrier function and psoriasis.
出处
《医学综述》
2016年第7期1255-1258,共4页
Medical Recapitulate
