长链非编码RNA在消化系统肿瘤转移中的研究进展

Research Progress of Long Noncoding RNA in the Metastasis of Digestive System Cancers

近年来消化系统肿瘤已成为全球最多发的恶性肿瘤之一,而肿瘤转移更是导致患者死亡的主要原因。长链非编码RNA(lncRNA)可通过染色体修饰、组蛋白修饰、DNA甲基化等转录前调控、转录及转录后水平调控发挥作用,可为消化系统肿瘤转移早期诊断和治疗提供生物标志和潜在药物靶点,从而提高患者生存率。该文就lncRNA与消化系统肿瘤转移的关系进行综述。

In recent years,the digestive system tumor has become one of the world’s most common malignant cancers,and tumor metastasis is the leading cause of death. Long noncoding RNA（ lncRNA） work through pretranscriptional,transcriptional and post-transcriptional regulation including chromosome modification,histone modification,DNA methylation and others,which may provide diagnostic markers and treatment targets,thus improving the survival rate of the patients. Here is to make a review of the relationship between lncRNA and the metastasis of digestive system tumors.