结核性与恶性胸腔积液中IL-6、IL-8、IL-18的表达水平及其意义被引量：3

Expression and diagnose value of IL-6, IL-8, IL-18 in tuberculosis and malignant pleural effusion

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摘要目的探讨白细胞介素-6（interleukin-6,IL-6）、白细胞介素-8（interleukin-8,IL-8）、白细胞介素-18（interleukin-18,IL-18）在结核性与恶性胸腔积液中的表达水平及其临床意义。方法采用酶联免疫吸附法（ELISA）检测本院2014年10月～2015年10月收治的56例结核性胸膜炎患者、42例恶性肿瘤患者的胸腔积液中IL-6、IL-8、IL-18的表达水平。结果结核性胸膜炎患者胸腔积液中IL-6表达水平为（510.3±42.1）pg/m L,IL-8表达水平为（1131.2±21.4）pg/m L,IL-18表达水平为（795.6±30.2）pg/m L;恶性肿瘤患者的胸腔积液中IL-6表达水平为（212.4±40.9）pg/m L;IL-8表达水平为（1084.8±11.0）pg/m L,IL-18表达水平为（367.3±22.4）pg/m L。结核性胸膜炎患者胸腔积液中IL-6、IL-18表达水平显著高于恶性肿瘤患者（P〈0.05）,IL-8表达水平比较差异无统计学意义（P〉0.05）。结论结核性胸膜炎患者胸腔积液中IL-6、IL-18表达水平显著高于恶性肿瘤患者,可作为临床鉴别诊断的参考指标。 Objective To determine the levels and diagnose value of IL-6, IL-8, IL-18 in tuberculosis and malignant pleural effusion. Methods Enzyme-linked immtmosorbent assay（ELISA） was used to evaluate the levels of IL-6, IL-8,IL-18 in 56 cases of tuberculosis pleural effusion, 42 cases of malignant pleural effusion who were hospitalized from Oct 2014 to Oct 2015. Results The levels of IL-6, IL-8, IL-18 in tuberculosis pleural effusion patients were（510.3±42.1 pg/m L, 1131.2±21.4 pg/m L and 795.6±30.2 pg/m L）. Whereas the levels of IL-6, IL-8, IL-18 in malignant pleural effusion patients were（212.4±40.9 pg/m L, 1084.8±11.0 pg/m L, 367.3±22.4 pg/m L）. The levels of IL-6 and IL-18 in tuberculosis pleural effusion were significantly higher than that in malignant pleural effusion（P〈0.05）, while the level of IL-8 in two groups showed no significantly difference（P〈0.05）. Conclusion The levels of IL-6, IL-18 in tuberculosis and malignant pleural effusion are different, which could be used as a reference indicator.

作者武忠长

机构地区辽宁省辽阳市结核病医院检验科

出处《中国现代医生》 2016年第7期94-96,F0003,共4页 China Modern Doctor

关键词结核胸腔积液 IL-6 IL-18 IL-8 Tuberculosis Pleural effusion IL-6 IL-18 IL-8

分类号 R521.7 [医药卫生—内科学]

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