东莞樟木头地区高尿酸血症与心血管危险因素分析

Analysis of hyperuricemia and risk factors of cardiovascular disorders in Zhangmutou District of Dongguan

目的探讨东莞樟木头地区体检人群高尿酸血症与心血管危险因素的关系。方法分析2012年1月。2014年12月在东莞樟木头地区健康体检中所有血尿酸水平男性及绝经后女性大于420μmol／L、绝经前女性大于350μmol／L的体检者资料共1913例，包括年龄、性别、血尿酸、血清肌酐、空腹血糖及血压。应用统计软件分析高尿酸血症相关因素及对心血管危险因素的影响。结果高尿酸血症患者的血尿酸水平与男性、血清肌酐、收缩压及舒张压水平呈正相关（r=0．44，0．24，0．06，0．18，P均〈0．01）。高尿酸血症患者3个血压分组任何2组间血尿酸水平的差异均具有统计学意义（P均〈0．01）。结论高尿酸患者高血压病患病率明显高于正常人群。血压异常、血清肌酐升高的男性患者更容易合并有高尿酸血症。高尿酸血症患者的血尿酸水平与高血压病密切相关。

Objective To investigate the relationship between hyperuricemia and risk factors of car- diovascular diseases in the subjects from Zhangmutou District of Dongguan during physical examination. Meth- otis Between January 2012 and December 2014, clinical data including age, gender, serum uric acid, serum creatinine, fasting blood glucose and blood pressure, of 1 913 cases, the male with serum uric acid level 〉 420 μmol/L and the female with the value 〉 350μmol/L, were retrospectively analyzed. The risk factors of hype- ruricemia and the effect upon cardiovascular diseases were evaluated by statistical software. Results In pa- tients with hyperuricemia, serum uric acid level was positively correlated with male gender, serum ereatinine level, high systolic pressure and diastolic pressue （r =0. 44, 0. 24, 0.06, 0. 18, P all 〈 0. 01 ）. Serum uric acid levels significantly differed between either two among the three groups according to the blood pressure （P 〈 0. 01 ）. Conclusions The incidence of hypertension in patients with hyperuricemia was significantly higher compared with that in the healthy counterparts. Male subjects with abnormal blood pressure and elevated level of serum creatinine are more likely to be complicated with hyperuricemia compared with alternative counter- parts. Serum uric acid level is intimately correlated with hypertension in patients with hyperuricemia.