序贯疗法治疗急性缺血性脑血管病的疗效观察

Therapeutic effect of sequential therapy on acute ischemic cerebral vascular disease

目的探讨序贯疗法治疗急性缺血性脑血管病的效果。方法选取漯河市中心医院收治的急性缺血性脑血管病患者80例作为研究对象，采用数字随机表将患者分为对照组和观察组，对照组予以阿司匹林联合复方丹参注射液治疗；观察组予以降纤酶、奥扎格雷钠、盐酸丁咯地尔液序贯治疗。所有患者行神经功能缺损评分（NIHSS），检测治疗前后纤维蛋白原（Fib）变化情况，评估I晦床疗效，记录不良用药反应。结果观察组治疗有效率为80．0％，显著高于对照组的57．5％，差异有统计学意义（P〈0．05）；观察组治疗后NIHSS评分为（10．06±1．69）分，较对照组低，差异有统计学意义（P〈0．05）；观察组治疗后全血黏度、血浆黏度、Fib分别为（3．96±0．88）mPa．s、（1．18±0．21）mPa·s、（2．03±0．82）g/L，均低于对照组，差异有统计学意义（P〈0．05）。结论序贯疗法治疗急性缺血性脑血管病，能够改善血液流变学，减轻神经功能缺损程度，提高临床疗效。

Objective To investigate the effect of sequential therapy on acute ischemic cerebral vascular disease. Methods Eighty patients with acute ischemic cerebral vascular disease admitted into the central hospital of luohe were selected as the research objects and were divided into the observation group and the control group by the random number table. The control group was treated with aspirin combined with compound salvia miltiorrhiza injection while the observation group with defibrase, sodium ozagrel and buflomedil hydrochloride sequential therapy. The National Institutes of Health Stroke Scale （NIHSS） was scored. The changes of fibrinogen （Fib） before and after the treatment were detected. The clinical efficacy was evaluated and adverse drug reactions were recorded. Results The effective rate of the observation group was 80% , which was significantly higher than that of the control group（ 57.5% ） , the difference was significant （ P 〈 0.05 ） ; the NIHSS score of the observation group after the treatment was （ 10.06 ± 1.69 ） % , which was lower than that of the control group, the difference was significant （ P 〈 0.05 ） ; the whole blood viscosity, plasma viscosity and Fib of the observation group after the treatment respectively were （3.96 ± 0.88 ） mPa · s, （ 1.18 ± 0.21 ） mPa· s and （2.03 ± 0.82） g/L, which were lower than those of the control group, the differences were significant （ P 〈 0.05 ）. Conclusions Sequential therapy in the treatment of acute ischemic cerebral vascular disease can improve hemorheology, relieve the degree of neural function defect and improve the clinical efficacy.