摘要
目的比较小剂量曲马多联合阿米替林、加巴喷丁和单独应用卡马西平治疗丘脑痛的疗效和不良反应发生情况。方法选取沈阳军区总医院2010年2月至2013年9月诊断为丘脑痛患者50例,按随机数字表分法分为治疗组和对照组,每组各25例。治疗组患者联合口服曲马多(50 mg/次,2次/d)、阿米替林(25 mg/次,3次/d)和加巴喷丁(0.3 g/次,2次/d);对照组口服卡马西平(0.3 g/次,3次/d),连续4周。视觉模拟评分法(VAS)评估镇痛效果,并计算临床有效率,观察不良反应发生情况。结果治疗组治疗后VAS值明显低于对照组(P<0.05)、临床有效率明显高于对照组(P<0.05),两组不良反应均轻微。结论小剂量曲马多联合阿米替林、加巴喷丁治疗丘脑痛,疗效较卡马西平更好,且不良反应轻微。
Objective To explore low dose of tramadol combined amitriptyline,gabapentin and separate application of carbamazepine in the treatment of thalamic pain curative effect and adverse reactions occured. Methods Totally 50 patients with thalamic pain were randomly divided into treatment group（ n = 25） and control group（ n = 25）. Patients in treatment group received tramadol（ 50 mg,twice per day）,amitriptyline（ 25 mg,3 times per day） and gabapentin（ 0. 3 g,twice per day） for four weeks. Patients in control group received carbamazepine（ 0. 3 g,3 times per day） instead. Visual analogue scale（ VAS） was used to evaluate analgesic effect. The clinical effective rate was calculated. The adverse reactions were observed.Results The VAS score after treatment was significantly lower in treatment group than that in control group（ P〈0. 05）,the clinical effective rate was significantly higher in treatment group than that in control group（ P〈0. 05）. The adverse reactions were mild in both groups. Conclusion The effect of low dose tramadol combined with amitriptyline and gabapentin on thalamic pain is better than carbamazepine with mild adverse reactions.
出处
《创伤与急危重病医学》
2016年第2期83-86,共4页
Trauma and Critical Care Medicine
基金
辽宁省自然科学基金(2013020194)
沈阳市科技计划项目(F14-158-9-11)
