新疆维、汉民族TGF-β_1血浆蛋白浓度在动脉瘤患者中表达及意义

The expression and significance of the plasma protein concentration of TGF-β_1 in the patients with aneurysm of Xinjiang Uygur and Han Nationalities

目的探讨转化生长因子-β_1(TGF-β_1)血浆蛋白浓度在新疆维吾尔族和汉族人群中的表达及意义。方法采用酶联免疫法(ELISA法)检测60例非动脉瘤患者血浆(对照组)、120例颅内动脉瘤患者(研究组)血浆TGF-β_1的表达水平,分析TGF-β_1血浆蛋白浓度与民族的相关性以及在动脉瘤患者和非动脉瘤患者中的差异性表达。结果研究组患者血浆TGF-β_1的浓度明显高于对照组,并且新疆维吾尔族颅内动脉瘤患者TGF-β_1的浓度明显高于汉族颅内动脉瘤患者。结论血浆TGF-β_1高表达可能与颅内动脉瘤有关。TGF-β_1高表达在动脉瘤的形成、变大、破裂的过程中可能与民族差异性相关。

Objective To investigate the expression and significance of transforming growth factor-β1（ TGF-β1） plasma protein in Xinjiang Uygur and Han population. Methods Using enzyme linked immunosorbent assay（ ELISA） to detect plasma TGF-β1expression level in 60 cases with non aneurysm,120 cases with intracranial aneurysm. Correlations of TGF-β1between plasma protein concentration and ethnic differences in patients with non aneurysm and with aneurysm were analyzed. Results The plasma concentration of TGF-β1in observed group was obviously higher than that of control group,and concentration of TGF-β1in the patients with intracranial aneurysm of Xinjiang Uygur was obviously higher than that of the Han nationality. Conclusion Plasma TGF-β1high expression may be associated with intracranial aneurysm. TGF-β1high expression in the formation of an aneurysm,larger,the rupture process and the ethnic differences may be positively correlative.