纤畅茶对小鼠通便作用考察

Study on Laxative Effect of Xianchang Tea in Mice

目的:研究纤畅茶对便秘模型小鼠通便作用的影响。方法:将小鼠随机分为空白对照组、模型对照组和低、中、高剂量组(2.275,4.55,13.65 g·kg^(-1))。分别灌胃给予生理盐水和纤畅茶14 d后,模型对照组和3个剂量组用复方地芬诺酯建立小鼠便秘模型,观察纤畅茶对小鼠体质量、小肠推进运动和给药后6 h内排便的影响。结果:13.65 g·kg^(-1)剂量可显著提高肠蠕动抑制模型小鼠的小肠墨汁推进率(P<0.05),显著缩短便秘小鼠排首粒黑便时间(P<0.05),4.55,13.65 g·kg^(-1)剂量可显著增加便秘小鼠排粪便量(P<0.05),各剂量对便秘小鼠的排便粒数无显著影响(P>0.05)。各剂量不使小鼠发生腹泻,且对小鼠的体质量增长无显著影响。结论:纤畅茶对小鼠具有通便功能。

Objective： To study the laxative effect of Xianchang tea in mice. Methods： The mice were randomly divided into the blank control group,the model control group,the low dose group,the medium dose group and the high dose group（ 2.275 g·kg^（-1）,4.55 g·kg^（-1）and 13.65 g·kg^（-1））. The mice were treated with 0.9% normal saline solution or Xianchang tea through intragastric administration once a day for 14 days. The mice in the model control group and the three dose groups were established the constipation model with compound diphenoxylate. The weight of mice,small intestine motor and defecation effect after the 6-hour administration were observed. Results： The small intestine motor experiments showed that the ink-impelling ratio of the high dose group was increased（ P〈0.05） and the time of the first ink defecation was shorter（ P〈0.05）. The feces weight in 4.55 and 13.65 g·kg^（-1）dose groups were increased（ P〈0.05）. The feces quantity of the three dose groups showed no significant difference when compared with that of the control group（ P〉0.05）.Conclusion： Xianchang tea has a positive laxative effect in mice.