S100B蛋白在临床中应用研究进展

Clinical application of the S100B Protein

1 S100B蛋白1.1 S100B蛋白概述S100B蛋白因在中性饱和硫酸铵的溶解度为100%而得名,是一种脑特异性钙结合蛋白,广泛存在中枢系统内。该蛋白是多基因编码的,由α和β2种亚基组成的蛋白分子量为21KD酸性钙结合蛋白。主要由神经胶质细胞合成分泌,尤其是星形胶质细胞和少突质细胞,

S100B is a calcium-binding protein most abundant in neuronal tissue.Depending on the concentration,secreted S100B exerts either trophic or toxic effects.Its functions have been extensively studied but are still not fully understood.Increased S100B level in blood can be seen in head injury,certain neurodegenerative diseases, cerebrovascular diseases and malignant melanoma.It has a great sensitivity and specificity,which can assist early diagnosis,assess the severity,treatment and prognosis with a far-reaching significance.In this paper,we provides a short background of protein S100B about the structure,distribution,function,commercially available methods of analysis,and its clinical use.