啶氧菌酯的合成工艺优化

Synthesis of Picoxystrobin

[目的]研究新型杀菌剂啶氧菌酯的合成工艺。[方法]以邻甲基苯乙酸为原料,经酯化、酯缩合、甲基化、氯化、醚化反应5步合成啶氧菌酯。[结果]在优化的反应条件下,总收率44.2%,纯度99%。[结论]该工艺收率高、操作简便、产品纯度高,适合工业化生产。

[Aims] This paper aims tooptimize and improve the synthetic process of picoxystrobirL [Methods] Picoxystrobin was synthesized via esterification, ester condensation, methylation, chloration and etherification from o-tolylacetic acid. [Results] Under the optimal conditions, the total yield was 44.2% based on o-tolylacetic acid and the purity was 99%. [Conclusions] The process has some advantages of high yield, simple operation and high purity, which is suitable for industrial manufacture.