益生菌联合三联疗法治疗儿童幽门螺杆菌感染的观察

Clinical Effect of Probiotics Combined with Triple Therapy in the Treatment of Helicobacter Pylori Infection in Children

目的:探讨益生菌联合三联疗法对儿童幽门螺杆菌感染根除率和不良反应的影响。方法:采用随机对照研究,选取具有上消化道不适症状并符合诊断标准的幽门螺杆菌感染患者150例,随机分为2组。三联疗法组75例采用标准三联疗法治疗,益生菌组75例在三联疗法基础上加用益生菌,疗程均为14 d。记录2组治疗过程中的不良反应。治疗结束4周后复查13C呼气试验,比较2组患者幽门螺杆菌的根除率及不良反应的发生率。结果:三联疗法组幽门螺杆菌根除率为76.00%(57/75),益生菌组为90.67%(68/75),益生菌组根除率高于三联疗法组(P<0.05)。益生菌组的患者食欲减退、便秘及腹泻不良反应发生率均明显低于三联疗法组(P<0.05);恶心、呕吐、口腔炎在2组间无显著性差异(P>0.05)。结论:益生菌联合三联疗法能提高幽门螺杆菌的根除率,降低药物的一些不良反应。

Objective： To determine the effects of the probiotics adding triple therapy in improving the Helicobacter pylori eradication rate and minimizing- the side- effects prevalence. Methods： A randomized controlled study was conducted in 150 children,which had upper gastrointestinal symptoms and were diagnosedas Helicobacter pylori infection. These patients were randomized into triple therapy（ n = 75） and adding probiotics groups（ n = 75）. The course of treatment was 14 days in both groups. The side- effects of the treatment were determined in each group. Helicobacter pylori eradiation was evaluated by13 C breath tests at 4 weeks after treatment,and the eradication rate and incidence of side- effect events were compared in the two groups. Results： The Helicobacter pylori eradication rates were 76. 00%（ 57 /75） in the triple therapy group and 90. 67%（ 68 /75）in the probiotics group,the rate of Helicobacter pylori eradication was significantly higher in probiotic group（ P〈0. 05）. Compared with the triple therapy group,the probiotics group had a lower rates of poor appetite,constipation,and diarrhea（ P〈0. 05）,but no lower rates of nausea,vomiting,and stomatitis（ P〈0. 05） during treatment. Conclusion： Probiotics combined with triple therapy can significantly increase Helicobacter pylori eradication rate,and reduce the incidence of poor appetite,constipation,and diarrhea during treatment.