女性下生殖道HPV不同感染类型的血清INF-ε水平被引量：1

Serum INF- ε Level of Women with Human Papilloma Virus Infection in Low Genital Tract

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摘要目的:探讨女性下生殖道人乳头瘤病毒(HPV)感染类型与血清干扰素-ε(INF-ε)水平的关系。方法:将2014年1月至2015年1月在我院确诊为下生殖道HPV感染的女性患者230例作为研究对象,依据HPV感染的类型分为HPV低危型感染组(105例)和HPV高危型感染组(125例),选取同期妇科健康体检的妇女(30例)作为对照组。3组都进行血清INF-ε水平和HPV感染及类型的检测。结果:对照组与HPV低危型感染组之间的血清INF-ε水平无显著性差异,而HPV高危型感染组血清INF-ε水平显著低于对照组(P<0.05)。结论:女性下生殖道HPV高危型感染者血清INF-ε水平下降。 Objective： To explore the relationship between Serum INF- εlevel and the type of Human Papillomavirus Infection in low genital tract of female. Methods： In 230 cases of HPV infection in shiyan Hospital during Jan. 2014 to Jan. 2015 which were divided by HPV test to 105 patients with Low- risk Human Papilloma virus Infection and 125 patients with high- risk Human Papillomavirus Infection. 30 heath women of taking physical health examination were control group. serum INF- εlevel were detected in the three groups. Results： There was no difference between the heath women and the patients with Low- risk Human Papilloma virus Infection in INF- εlevel. The women with high- risk Human Papilloma virus Infection in low genital tract were obviously lower than heath women in INF- εlevel. Conclusion： The Serum INF- ε level is low in women with hign- risk Human Papillomavirus Infection in low genita l tract.

作者许燕丽邹丽兰陈婉秋

机构地区深圳市宝安区石岩人民医院妇产科

出处《现代临床医学》 2016年第2期134-135,共2页 Journal of Modern Clinical Medicine

关键词人乳头瘤病毒干扰素-ε 高危型 human papilloma virus interferon-ε high-risk type

分类号 R711.7 [医药卫生—妇产科学]

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1BOSCH F X, MANOS M M, MUNOJ N, et al. Prevalence of human papilloma virus in cervical cancer [ J ]. a worldwide perspective. JNatl Cancer Inst, 1995, 87 ( 11 ) : 796 - 802.
2李慧弘,肖长义.人乳头瘤病毒与生殖系统肿瘤[J].肿瘤学杂志,2010,16(11):864-868. 被引量：12
3HERVAS - STUBBS S, PEREZ - GRACIA J L, ROUZAUT A, et al. Direct effects of type I interferons on cells of the immune system [ J ]. Clin Cancer Res, 2011, 17(9) : 2619 -2627.
4WIJESUNDARA D K, YANG Xi, RANASINGHE C, et al. Unraveling the convoluted biological roles of type I interferons in infection and immunity: a way forwardfor therapeutics and vaccine design [ Z], 2014: 412.
5FUNG K Y, MANGAN N E, CUMMING H, et al. Interferon- e protects the female reproductive tract from viral and bacterial infection [J]. Science, 2013, 339(6123): 1088-1092.
6HERMANT P, FRANCIUS C, CLOTMAN F, et al. IFN - ~ is constitutively expressed by cells of the reproductive tract and is inefficiently secreted by fibroblasts and cell lines [ J ]. PLoS One, 2013, 8(8) : e71320.

二级参考文献22

1Schottenfeld D, Bcebehe-diminer JL. Advances in cancer epidemlology: understanding causal mechanisms and the evidence for implementing interventions [J]. Annu Rev Public Health, 2005, 26:37-60.
2Bulk S, Berkhof J, Bulkmans NW, et al. Preferential risk of HPV16 for squamous cell carcinoma and of HPV 18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands[J]. Br J Cancer, 2006, 94(1): 171-175.
3Chen W, Zhang X, Molijn A, et al. Human papillomavirus type-distribution in cervical cancer in China: the impor- tance of HPV 16 and 18[J]. Cancer Causes Control, 2009, 20(9):1705-1713.
4Altekruse SF, Lacey JV, Brinton LA,et al. Comparison of human papillomavirus genotypes, sexual, and reproductive risk factors of cervical adcnocarcinoma and squamous cell carcinoma: Northeastern United States [J]. Am J Obstet Gynecol, 2007, 188(3):657-663.
5Bulkmans NW, Berkhof J, Bulk S, et al. High-risk HPV type-specific clearance rates in cervical screening[J]. Br J Cancer, 2007, 96(9):1419-1424.
6Song SH, Lee JK, Oh M J, et al. Risk factors for the pro- gression or persistence of untreated mild dysplasia of the uterine cervix[J]. Int J Gynecol Cancer, 2006, 16(4):1608- 1613.
7Nunez-Troeonis J, Delgado M, Gonzalez J, et al. Preva- lence and risk factors of human papillomavirus infection in asymptomatic women in a Venezuelan urban area[J]. Invest Clin, 2009, 50(2):203-212.
8Wu QJ, Guo M, Lu ZM, et al. Detection of human papillo-mavims-16 in ovarian malignancy [J]. Br J Cancer,2003, 89(4):672-675.
9Atalay F, Taskiran C, Taner MZ, et al. Detection of human papillomavirus DNA and genotyping in patients with epithe- lial ovarian carcinmna [J]. J Obstet Gynaecol Res, 2007, 33(6): 823-828.
10Sutton BC, Allen RA, Moore WE, et al. Distribution of hu- man papillomavirus genotypes in invasive squamous carci- noma of the vulva[J]. Mod Pathol, 2008, 21(3):345-354.