蛋白质组学在评估呼吸系统疾病严重程度的研究进展

Progress of proteomics in the diagnosis and treatment of respiratory critical illness

呼吸系统危重症疾病病情重、病死率高、治疗费用高。目前许多呼吸系统危重症发生发展机制并没有明确，许多呼吸系统危重症的发生、发展机制有待进一步探讨，其预警、预后、严重度评估的指标较少，限制了呼吸系统危重症的诊断和治疗。国内外学者已经开始关注并探讨呼吸系统危重症疾病患者蛋白质组学的变化及其特点，用以筛选和发现相关生物标志物，为呼吸系统危重症疾病发展机制、发生预警、治疗预后等探讨提供技术支持。本文就近年来蛋白质组学在呼吸系统危重症疾病诊治中的研究进展进行综述。

Respiratory system critical illnesses had a high mortality and a high cost of treatment. At present, the early diagnosis, prognosis and severity of the respiratory system critical illness, including severe pulmonary tuberculosis have not been clearly defined. Some studies have begun to pay attention to patients with critical illness, and to screen and identify biomarkers, to get the specific and sensitive biomarkers of severe secondary pulmonary tuberculosis and provide important reference for clinical diagnosis and treatment. In this paper, the research progress of proteomics in the diagnosis and treatment of respiratory system diseases in recent years was reviewed.