可变剪接在神经发育过程中对生物学功能的影响

Progress on Alternative Splicing in Neurodevelopment

可变剪接(alternative splicing)发生在前体m RNA向成熟m RNA的转换过程中,是转录后表达调控和产生蛋白质多样性的重要机制。可变剪接在真核生物中普遍存在,神经系统发育作为一个极其复杂且严密的过程,可变剪接对它的影响更明显。近年来,一些参与神经发育的可变剪接事件已经得到一定程度的验证,可以得知它的发生影响了突触生长、突触传递和神经干细胞的形成等生物学功能。同时,当可变剪接的模式发生改变时往往也会造成神经系统的功能异常。因此,本文就可变剪接的机制进行了简短的介绍,探索其在神经发育及神经疾病中的作用,并简单总结了相关数据库。

Alternative splicing is a major mechanism which regulates gene expression and generates much of the enormous protein diversity. It occurs in transcription process from pre-m RNA to mature m RNA. Alternative splicing is widespread in eukaryotes,development of nervous system is a extremely complex and rigorous process, alternative splicing could affect it more obvious than on the simple process. In recent years, many alternative splicing events which participate in neural development has gained a certain degree of verification, that influence corresponding biological function, such as synaptic growth, synaptic transmission and the formation of neural stem cells. When the alternative splicing pattern changes, also tend to cause abnormal function of the nervous system.In this paper, the mechanism of alternative splicing was introduced, and its relationship with neural development and neural diseases was discussed. The current common database are also summarizes.