齐拉西酮与奥氮平治疗早期精神分裂症的疗效与安全性

Curative Effect and Safety of Ziprasidone and Olanzapine in the Early Schizophrenia

目的:探讨齐拉西酮与奥氮平治疗早期精神分裂症患者的临床效果及用药安全性。方法:回顾性分析2014年9月-2015年9月来本院就诊的74例早期精神分裂症患者,根据治疗方法的不同分为两组,其中对照组37例给予奥氮平治疗,观察组37例则给予齐拉西酮治疗,比较两组疗效及不良反应发生情况。结果:治疗后2、4、8周,两组PANSS评分均优于治疗前,且观察组PANSS评分优于对照组,比较差异均有统计学意义(P<0.05);两组治疗后2、4、6周CGI两项评分比较,差异均无统计学意义(P>0.05);治疗8周后,观察组CGI两项评分明显优于对照组,比较差异均有统计学意义(P<0.05);治疗后2、4、6、8周,观察组TESS评分均低于对照组,比较差异均有统计学意义(P<0.05)。结论:对于早期精神分裂症患者,齐拉西酮治疗的效果及安全性均要优于奥氮平,因此建议首选齐拉西酮治疗控制病情。

Objective： To study the clinical effect and drug safety of Ziprasidone and Olanzapine in patients with early schizophrenia.Method： 74 patients with early schizophrenia in our hospital from September 2014 to September 2015 were reviewed.They were divided into two groups according to different therapies.37 patients in the control group adopted Olanzapine for treatment and 37 patients in the observation group adopted Ziprasidone for treatment.The curative effect and the incidence of adverse events of the two groups were compared.Result： After 2, 4 and 8 weeks of treatment, the PANSS scores of the two groups were better than before and the PANSS scores of the observation group were better than those of the control group, the differences were statistically significant （ P〈0.05 ） .After 2, 4 and 6 weeks of treatment, the differences in the two CGI scores of the two groups were not statistically significant （P〉0.05） .After 8 weeks of treatment, the two CGI scores of the observation group were better than those of the control group, the differences were statistically significant （P〈0.05） .After 2, 4, 6 and 8 weeks of treatment, the TESS scores of the observation group were better than those of the control group, the differences were statistically significant （ P〈0.05 ） .Conclusion： For patients with early schizophrenia, Ziprasidone has a better effect and higher safety than Olanzapine.Ziprasidone is preferred to control the disease.