2011～2013年广东省吸毒人群丙肝感染状况及危险因素分析

Analysis on HCV seroprevalence and related risk factors among drug users,Guangdong province,2011-2013

目的了解广东省吸毒人群HCV的感染状况及影响HCV感染的危险因素,为政府制定预防策略和措施提供参考依据。方法基于2011~2013年广东省艾滋病吸毒人群哨点监测数据,采用描述性统计方法分析吸毒者的人口学、行为学特征,对可能影响HCV感染的危险因素进行单因素和多因素Logistic回归分析。结果吸毒哨点共检46 529人,55.44%有注射吸毒史,30.84%的调查对象共用针具,61.00%最近1个月有注射毒品,35.91%近一个月注射吸毒时有公用针具;HCV阳性率为46.51%。单因素分析结果显示,性别、年龄、文化程度、婚姻、注射吸毒、共用针具、不安全性行为是HCV感染的危险因素（P〈0.01）;多因素Logistic回归分析结果显示,HCV感染的主要危险因素为注射吸毒（OR=11.19,95%CI：2.40~52.11）,共用针具（OR=2.07,95%CI：1.84~2.33）,年龄（20~、30~、40岁~）（OR=2.34,95%CI：1.44~3.80;OR=5.57,95%CI：3.44~9.02;OR=5.40,95%CI：3.31~8.84）,未婚（OR=1.51,95%CI：1.26~1.82）。结论广东省吸毒人群HCV感染率较高,该人群存在着丙肝传播与流行的危险因素,是丙肝防治的重点人群。对吸毒人群的高危行为应实施更有针对性的健康教育和行为干预综合防治措施。

Objective To understand the seroprevalence of HCV among drug users（DUs）and the risk factors related to HCV infection in Guangdong province,so as to provide basis for working out prevention and control strategies and measures by the government. Methods The surveillance data of 2011-2013 collected from all drug users in Guangdong province surveillance system were analyzed.Demographic and behavioral characteristics were analyzed by descriptive statistical method.Univariate and multivariate logistic regression analysis were used to analyze the influencing factors of infection.Results A total of 46 529 drug users were recruited.Of the investigation objects,55.41% were injecting drug users,of whom 30.84% shared needles and syringes with others.61.00% drug users had injected last month,of whom 35.91%shared needles and syringes with others last month.The seroprevalence of HCV infection was 46.51%.The single factor analysis showed that gender,age,culture degree,marriage,injection drug use,needle sharing and unsafe behavior were related with the HCV infection.Multivariate logistic regression analysis showed injection drug use（OR =11.19,95%CI ：2.40-52.11）,needlesharing（OR =2.07,95%CI ：1.84-2.33）,age（20-,30-,40-）（OR =2.34,95%CI ：1.44-3.80,OR=5.57,95%CI ：3.44-9.02,OR =5.40,95%CI ：3.31-8.84）,and unmarried（OR =1.51,95%CI ：1.26-1.82）were closely related to HCV infection. Conclusion The positive rate is much higher in DUs than normal population in Guangdong province,suggesting that the special group has risk factors for HCV epidemiology,and should get more attention in prevention and control of HCV infection.More targeted integrated measures to DUs on health education and behavioral intervention should be performed for prevention and control.