喜炎平联合利巴韦林治疗小儿手足口病的临床效果观察

Observation on clinical effect of xiyanping combined ribavirin treatment of infantile hand-foot-mouth disease

目的探讨应用喜炎平联合利巴韦林治疗小儿手足口病的临床效果。方法 74例手足口病患儿依照随机分配原则分为对照组37例与实验组37例,对照组在常规治疗基础上予以利巴韦林治疗,实验组则在对照组基础上追加喜炎平治疗,7d为1个疗程,尔后评估比较两组患儿治疗效果、疾病相关指标等,并对用药安全性进行评析。结果实验组患儿的治疗总有效率高达94.6%,较之于对照组的72.9%,差异有统计学意义(P<0.05);实验组患儿的体温恢复正常时间、疱疹消退时间、皮疹消退时间及治愈时间等均较对照组更短,差异有统计学意义(P<0.05);两组患儿均无明显不良反应。结论应用喜炎平联合利巴韦林治疗小儿手足口病有助于患儿临床症状与体征的迅速改善,且用药安全性高,治疗效果较为理想,建议临床采纳推广。

Objective To analyze the clinical effect of xiyanping combined ribavirin in the treatment of infantile hand-foot-mouth disease. Methods 74 children patients with infantile hand-foot-mouth disease,who were selected as the research objects,were randomly divided into control group and test group,with 37 cases in each group.To treat with ribavirin based on routine treatment on control group,to treat with supplemental xiyanping treatment on test group based on control group,with the treatment course of 7d.To evaluate and compare the treatment effect and the interrelated index of disease of patients between the two groups,and to analyze safety of drug use. ResultsThe total treatment effective rate in test group 94.6% was obviously higher than which in control group 72.9%,the differences was statically significant（P〈 0.05）.The body temperature recovery time,the herpes regression time,the rash regression time,and the cure time and etc.Of patients in test group were significantly shorter than which in control group,the differences was statically significant（P 〈0.05）.There were non severe adverse reactions of the two groups.Conclusion Xiyanping combined ribavirin in the treatment of infantile hand-foot-mouth disease is conducive to rapidly improve the clinical symptoms and signs,has higher safety of drug use and better treatment effect,is worthy of clinical popularization.