血清LXA4与降钙素原在急性阑尾炎患者中的动态监测

Dynamic monitoring of serum LXA4 and procalcitonin in patients with acute appendicitis

目的通过动态监测急性阑尾炎患者手术前后外周血脂氧素A4（LXA4）与降钙素元（PCT）水平,分析LXA4、PCT在急性阑尾炎患者的诊断及预后中的作用。方法选取我院2011年3月~2015年6月,120例急性阑尾炎患者,采用酶联免疫吸附法（ELISA）检测术前及术后第2天（11~35h）患者外周血LXA4、PCT水平,并进行分析比较。结果 120例急性阑尾炎患者,结合手术或（和）病理诊断结果分为单纯性阑尾炎（35例）、化脓性阑尾炎（47例）、穿孔性及坏疽性阑尾炎（38例）。120例急性阑尾炎患者术前血清LXA4水平均高于术后（P〈0.05）;化脓性、穿孔性及坏疽性阑尾炎组术前血清LXA4水平高于单纯性阑尾炎组,差异具有统计学意义（P〈0.01）。化脓性、穿孔性及坏疽性阑尾炎组术后血清LXA4水平与单纯性阑尾炎组比较,差异无统计学意义（P〉0.05）。单纯性阑尾炎组及化脓性、穿孔性及坏疽性阑尾炎组术前血清PCT水平均高于术后（P〈0.05）,化脓性、穿孔性及坏疽性阑尾炎组术前血清PCT水平高于单纯性阑尾炎组,差异具有统计学意义（P〈0.01）。化脓性、穿孔性及坏疽性阑尾炎组术后血清PCT水平与单纯性阑尾炎组比较,差异无统计学意义（P〉0.05）。结论通过对急性阑尾炎患者血清LXA4与PCT水平的检测,对急性阑尾炎的诊断,手术评估,以及预后恢复方面,均有一定的指导意义。

Objective To analyze effects of LXA4 and PCT on the diagnosis and prognosis of patients with acute appendicitis by dynamic monitoring of peripheral blood lipoxin A4 （LXA4） and procalcitonin （PCT） levels. Methods 120 patients with acute appendicitis who were admitted to our hospital from March 2011 to June 2015 were selected.LXAd and PCT levels before operation and the second day after operation （11-35h） were monitored by Enzyme-linked immunosorbent assay （ELISA） and they were analyzed and compared. Results In 120 patients with acute appendicitis,there were 35 cases of simple appendicitis,47 cases of suppurative appendicitis and 38 cases of perforated appendicitis or gangrenous appendicitis according to the surgery or （and） pathological diagnosis results. The levels of the serum LXA4 before operation of 120 patients with acute appendicitis before the operation were all higher than those after operation （P 〈 0.05）.Preoperative serum LXA4 levels of the suppurative,perforated and gangrenous appendicitis groups were higher than that of the simple appendicitis group （P 〈 0.01） and the difference was statistically significant.The difference between simple appendicitis group and the suppurative, perforated and gangrenous appendicitis groups had no statistical significance （P 〉 0.05）.Preoperative serum PCT levels of the simple,suppurative,perforated and gangrenous appendicitis groups were all higher than those before operation （P 〈 0.05）. Preoperative serum PCT levels of the suppurative, perforated and gangrenous appendicitis groups were higher than that of the simple appendicitis group （P 〈 0.01）.And the difference was statistically significant.Postoperative serum PCT levels between suppurative,perforated and gangrenous appendicitis groups and the simple appendicitis group had no statistical significance （P 〉 0.05）. Conclusion Monitoring of serum LXA4 and PCT levels of acute appendicitis patients has certain guiding significance in diagnosis, operation assessment and the prognosis recovery of acute appendicitis.