缺氧诱导因子1α在组织工程成骨和成血管中的作用

DEVELOPMENT OF HYPOXIA-INDUCIBLE FACTOR 1α IN TISSUE ENGINEERED ANGIOGENESIS AND OSTEOGENESIS

目的总结缺氧诱导因子1α(hypoxia-inducible factor 1α,HIF-1α)在组织工程成骨和成血管中的作用和应用进展。方法查阅国内外关于HIF-1α在组织工程成骨和成血管中的相关研究文献,进行分析和归纳总结。结果 HIF-1α在成血管-成骨耦连反应中发挥关键作用,作为上游基因调控着体内多种成血管、成骨基因的表达;在组织工程骨的再生修复中,HIF-1α不仅调节和促进血管生成,并且对种子细胞尤其是干细胞增殖和分化有重要影响和意义,从而为骨缺损修复奠定基础。结论随着组织工程技术的发展,HIF-1α在应用中存在的有效剂量靶向控释、促炎和致癌等相关问题将逐步得到解决,以期更好应用于临床。

Objective To review the development and applications of hypoxia-inducible factor 1α（HIF-1α） in the strategy of tissue engineered angiogenesis and osteogenesis. Methods The literature about HIF-1α in tissue engineering technology was reviewed, analyzed, and summarized. Results HIF-1α plays a key role in angiogenicosteogenic coupling, and as an upstream regulator, HIF-1α can regulate the expressions of its target genes related with angiogenesis and osteogenesis. In addition, HIF-1α not only can control and improve the angiogenesis, but also has important significance in proliferation and differentiation of seed cells, especially stem cells, which is the foundation for bone healing. Conclusion With the development of tissue engineering technology, the problems in the applications of HIF-1α, such as the effective dose of targeting controlled-release, pro-inflammatory effect, and carcinogenicity, will be explored and solved in the future, so it can be used better in clinical.