乳腺浸润性小叶癌的诊断与治疗现状

Current status of diagnosis and treatment of invasive lobular breast carcinoma

乳腺浸润性小叶癌以癌细胞突破乳腺小叶内末梢乳管或腺泡基底膜而向小叶间质浸润性生长为主要特点。患者诊断时通常具有如下特点:年龄和肿瘤较大,腋窝淋巴结转移率较高,健侧容易发生。乳腺浸润性小叶癌通常具有较好的预后表型,低级别的组织学分级,较低的有丝分裂指数。浸润性小叶癌具有较高的侵袭性和广泛转移增殖倾向,与其它浸润性癌比较,预后较差。

Invasive lobular breast carcinomais mainly characterized byits infiltrating growth. Milk ductsin the breast lobulesandglandular acini on the basement membrane can be destroyed by cancer cell, which continued to infiltrate interstitial tissue. Diagnosed patients are usuallyaged sufferers with large tumor and metastasis, especially on the healthy side. The prognosis of invasive lobular breast carcinoma with low histologic grade and mitotic index is relatively good. For invasive lobular breast carcinoma with extensive invasion and metastasis, the prognosis is usually poor.