MicroRNA与特发性肺纤维化

MicroRNA and idiopathic pulmonary fibrosis

特发性肺纤维化（idiopathicpulmonaryfibrosis，IPF）是一种不明原因引起的以肺问质纤维化和肺功能损害为特点的进行性发展的肺部疾病，目前的治疗效果十分有限，存活期大概为诊断后的2．5～3．5年。虽然国内外有关肺纤维化的研究在不断取得新的进展，但迄今为止，IPF的发病机制仍不得而知。微小RNA（microRNA，miRNA）是一类由17～24个核苷酸构成的功能性非编码小分子RNA。近年来，miRNA因其对诸多生命活动的重要调控作用而备受关注，已经有部分miRNA被证明与肺纤维化的发病机制存在着密切的关系。本文将对miRNA与IPF的关系的研究进展作一综述。

Idiopathic pulmonary fibrosis （IPF） is a progressive, severe lung disease characterised by fibrosis of the lung mesenchyme and loss of lung function. Therapeutic options are limited for the patients who are suffering from IPF, and the median survival after diagnosis is approximately 2.5 to 3.5 years. Although domestic and international studies on pulmonary fibrosis are constantly in progress, but so far, the pathogenesis of IPF is still unknown. MicroRNA （miRNA） is a class of 17-24 nt small, noncoding RNA. In recent years, miRNA is concern with its important role in the regulation of many life activities. There have been some miRNAs proved to be closely related to the pathogenesis of pulmonary fibrosis. This article reviews the research progress of the relationship between miRNA and IPF.