多系统萎缩的睡眠结构研究

The sleep architecture in patients with multiple system atrophy

目的:探讨多系统萎缩(MSA)患者的睡眠结构改变。方法:选择MSA患者15例。同时纳入年龄、性别匹配的健康对照组19例。利用日本光电32导9200K脑电图机,所有患者均完成多导睡眠生理监测(PSG),记录脑电图、眼球运动、下颌和肢体肌电活动、心电图、经鼻气流、胸腹部呼吸运动、血氧、鼾声,并录像监测患者的行为。使用Polysmith软件分析呼吸、运动等相关指标,并视觉评估睡眠分期。结果:MSA组患者具有典型临床表现。和对照组相比,MSA组总体睡眠时间缩短、睡眠效率减低、Ⅱ期睡眠时间减少、低通气指数增高、周期性腿动(PLM)指数增高。全部MSA患者均呈现快速眼动期骨骼肌张力不消失,其中5例(30%)患者伴有夜间活动和言语。结论:MSA患者出现睡眠结构紊乱、呼吸紊乱以及PLM指数增高,并出现快速眼动期睡眠行为障碍(RBD),RBD可能具有提示诊断MSA的作用。

Objective：To investigate the changes of sleep structure in patients with multiple system atrophy （MSA）.Methods：Fifteen patients with MSA were included,19 age and sex matched healthy people recruited as control.All participants were video-mon＇itored with recordings of electroencephalography,electrooeulography and eleetromyography on the chins and limbs,electrocardiography,nasal airflow,thoracic and abdominal respi- ratory movement,oxygen and snore.The sleep architecture and other parameters were analyzed on the software of Polysmith and analyze sleep stages through vision.Results：Compared to healthy control,MSA group was found to have shorter total Sl^eep time and stage Ⅱtime,lower sleep efficieney.Meanwhile,hypopnea and periodic limb movement （PLM）indexlincreased.All patients with MSA had loss of atonia and five （30%）of them were recorded of night behaviors and talks.Conclusion：The MSA patients have sleep structure disorder,respiratory disorder,abnormal PLM and rfipid eye movement sleep behavior disorder.