原发性胆汁性肝硬化无创性肝纤维化诊断模型的验证

The noninvasive diagnostic models for primary biliary cirrhosis

目的验证采用常规实验室指标建立的无创性肝纤维化诊断模型,并评判其对原发性胆汁性肝硬化(PBC)患者组织学分期的诊断价值。方法采用受试者工作特征曲线下面积(AUC)检测各项无创诊断模型对PBC患者组织学分期的诊断价值。结果各项模型均对PBC的组织学分期有一定诊断价值,其中H指数、Forns评分及RPR预测价值最为突出,AUC分别可达0.851,0.811和0.843。结论由常规实验室指标建立的肝纤维化无创诊断模型H指数、Forns评分及RPR能协助准确区分PBC患者的早期(Ⅰ-Ⅱ期)和进展期(Ⅲ-Ⅳ期)病变。

Objective To verify the noninvasive diagnostic models of liver fibrosis in primary biliary cirrhosis（PBC）,and to assess its diagnostic value on histologic staging.Methods Diagnostic value of the models on histologic staging was assessed by the receiver operating characteristic curve（AUC）.Results The noninvasive diagnostic models had different levels of diagnostic values,especially H index,Forns Score and RPR,which could predict advanced fibrosis（stage III-IV）with an area under the receiver operating characteristic curve（AUROC）of 0.851,0.811 and 0.843,respectively.Conclusion The noninvasive models of H index,Forns Score and RPR,which were consisting of laboratory markers,could help accurately identify early（stage I-II）and advanced（stage III-IV）liver fibrosis in patients with PBC.