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PEG治疗肝性脑病 被引量:2

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摘要 近期Rahimi等随机对照研究表明聚乙二醇(PEG)治疗肝硬化肝性脑病的急性发作可能优于乳果糖。该项研究的发表,引发了我们一系列的思考。这一结论是否适用于所有患者?在临床工作中是否能达到预期效果?PEG是否适合重复使用以及它的安全性如何?肝性脑病是肝硬化最主要的并发症之一,它严重影响了患者的生活质量,增加了社会医疗负担[1]。
出处 《肝脏》 2016年第2期138-139,共2页 Chinese Hepatology
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  • 1Vilst rup H. Amodio P. Bajaj J, et al. Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by t he American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology, 2014,60: 715- 735.
  • 2Rahimi RS. Singal AG, Cuthbert JA,et al. Lactulose vs polyethylene glycol 3350-electrolyte solution for treatment of overt hepatic encephalopathy: the HELP randomized clinical trial. JAMA Intern Med.2014. 174: 1727-1733.
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  • 4Bajaj JS, Cordoba J, Mullen KD, et al. Review article: the design of clinical trials in hepatic encephalopathy-an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISH E"J) consensus statement. Aliment Pharrnacol Ther.2011 ,33: 739-747.
  • 5Hammer HF, Santa Ana CA, Schiller LR, et al, Studies of osmotic diarrhea induced in normal subjects by ingestion of polyethylene glycol and lacrulose, J Clin Invest .1989.84: 1056-1062.
  • 6Abu Hossain S, Chaudhry FA. Zahedi K, et al. Cellular and molecular basis of increased arnmoniagenesis in potassium deprivation. Am J Physiol Renal Physiol , 20 II .30 I : F969-F978.
  • 7Gorkiewicz G, Thallinger GG, Trajanoski S, et al. Alterations in the colonic microbiota in response to osmotic diarrhea. PLoS One. 2013,8: e55817.
  • 8van Berlo CL. van Leeuwen PA, Soeters PB. Porcine intestinal ammonia liberation. Influence of food intake. lacrulose and neomycin trearment.J Hepatol,1988,7:250-257.

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