某院呼吸内科住院患者抗菌药物使用情况的调查与分析

Investigation and Analysis about Use of Antimicrobial Agents in Patients of Department of Respiratory Medicine in A Hospital

目的调查与分析本院呼吸内科住院患者抗菌药物的使用情况,对其合理性进行比较和评价,促进临床合理用药。方法随机抽取本院呼吸内科2013-01~12期间出院病历360份,以Excel表格对抗菌药物的使用例数、使用种类、药敏试验、联合用药等进行分类统计结果。结果本院呼吸内科住院患者抗菌药物的使用率为93.6%,使用强度为42.5（DDD/100人天）;以静脉滴注（98.2%）和单用抗菌药（55.8%）为主;从用药频度看,以第三代头孢菌素（31.1%）、氟喹诺酮类（26.9%）和青霉素类（25.6%）为主。联合用药率为44.2%,病原学送检率为91.1%,发生药物不良反应5例,发生率1.4%。结论本院呼吸内科抗菌药物使用基本合理,但也有个别盲目联用抗菌药及盲目更换抗菌药或使用疗程不合理等现象,应进一步提高合理用药水平。

OBJECTIVE To investigate and analyze the use of antimicrobial agents in patients of Respiratory Medicine department in a hospital,to compare and evaluate its rationality,so as to improve the rational application of antimicrobials.METHODS A total of 360 medical records of discharged patients in a hospital from January to December in 2013 were randomly selected for the classification and statistics of the use of antimicrobial agents by Excel,covering case number,species,drug sensitivity test,combination drug therapy and so on.RESULTS The use rate of antimicrobial agents in patients of Respiratory Medicine department in a hospital was 93.6%,use density was 42.5 DDD/100 person day.Most case were intravenous injection（82.4%） and single-antimicrobial agents（55.8%）.As the frequency of the use of drugs,third-generation cephalosporins（ 31.1%）,Fluoroquinolones（26.9%） and Penicillins（25.6%） accounted for the large part.The use of drug combinations accounted for 44.2%,and pathogenic detection accounted for 91.1%.5 cases of drug adverse reactions occurred,accounting for 1.4%.CONCLUSION The use of antimicrobial agents in the department of Respiratory Medicine in a hospital is mostly reasonable,but there is still space for improvement,for there existed irrational usage of combination of antimicrobial agents,or replacing antimicrobial agents blindly,unreasonable course of treatment,etc.