左旋氨氯地平联合依拉普利在原发性高血压中的应用效果

The application effect of L-amlodipine combined with enalapril in essential hypertension

目的针对左旋氨氯地平联合依拉普利在原发性高血压中的应用效果进行分析研究。方法随机选择2014年1月至2015年2月我院收治120例原发性高血压患者，将其平均分为对照组和观察组，作为本次研究的对象。对照组患者实施左旋氨氯地平治疗，观察组患者实施左旋氨氯地平联合依拉普利治疗。针对观察组和对照组患者的临床治疗有效率，以及治疗的过程中患者发生的不良反应和血压等指标，进行对比分析。结果在本次研究中，治疗后观察组患者的血压与治疗前比较，差异有统计学意义（P〈0．05）；观察组患者治疗后的血压与对照组比较，差异有统计学意义（P〈0．05）。本次研究中观察组和对照组患者的临床治疗总有效率分别为96．67％、83．33％，差异有统计学意义（P〈0．05）。观察组与对照组患者在治疗过程中总不良反应发生率分别为5．00％、21．67％，差异有统计学意义（P〈0．05）。结论在原发性高血压患者的治疗中，使用左旋氨氯地平联合依拉普利治疗，其降压效果较好，且在治疗的过程中，患者产生的不良反应少，总体临床治疗效果显著，安全性较高。

Objective To analyze the application effect of L-amlodipine combined with enalapril in essential hypertension. Methods 120 cases of essential hypertension in our hospital from January 2014 to February 2015 were randomly selected as the research object and averagely divided into control group and observation group. Control group received L-amlodipine therapy, and observation group received L-amlodipine combined with enalapril therapy. Compared clinical treatment efficiency, the occurrence of adverse reactions, blood pressure of two groups. Results There was statistically significant difference in blood pressure before and after treatment in observation group （P〈0.05）, there was statistically significant difference in blood pressure between two groups after treatment （P〈0.05）. The overall clinical treatment efficiency of observation group and control group were 96,67%, 83.33%, with statistically significant difference （P〈0.05）. The incidence of adverse reactions in the process of treatment of observation group and control group were 5.00%, 21.67%, with statistically significant difference （P〈0.05）. Conclusion In the treatment of patients with essential hypertension, L-amlodipine combined with enalapril therapy has good antihypertensive effect, with fewer adverse reactions in the process of treatment, remarkable overall clinical effect, high security.