阵发性心房颤动的生物标记物

Biomarkers for diagnosing paroxysmal atrial fibrillation

阵发性心房颤动（PAF）约占所有心房颤动（AF）的50％，PAF作为一种过渡性心律失常显著增加血栓栓塞事件风险，但并未引起足够重视。目前，PAF不再被视为良性病变实体，早期发现或预测PAF具有重要的临床意义。本文从电生理、分子及形态学三方面阐述PAF的生物标记物，以期对PAF的早期诊断和预测提供帮助。

Paroxysmal atrial fibrillation （PAF） constitutes approximately half of all AF cases and is thought to represent an early stage of the disease. This intermittent form of atrial arrhythmia can be a challenge to identify and as a result many affected individuals are not prescribed appropriate antithrombotic therapy and hence are at risk of stroke and thromboembolism. PAF is no longer seen as a benign entity. As such potential biomarkers to detect PAF can be broadly categorised into electrophysiological, molecular, and morphological indices. This review aims to establish the available evidence for electrophysiological, molecular, and morphological biomarkers to improve the detection of PAF.