甲强龙分别联合两种茶碱类药物治疗慢性阻塞性肺疾病急性加重期疗效比较

Methylprednisolone combined with doxofylline versus aminophylline for chronic obstructive pulmonary disease in acute exacerbation period

目的探讨甲强龙分别联合两种茶碱类药物治疗慢性阻塞性肺疾病急性加重期的疗效。方法选择南阳医专二附院收治的慢性阻塞性肺疾病急性加重期患者100例，随机分为观察组和对照组，各50例。观察组在常规治疗基础上给予甲强龙联合多索茶碱治疗，对照组在常规治疗基础上给予甲强龙联合氨茶碱治疗。测定两组治疗前后动脉血气指标，观察不良反应情况，评定治疗效果。结果治疗后两组血气指标（pH值、PaO2、PaCO2）测定结果比较，差异无统计学意义（P〉0．05）。观察组总有效率高于对照组，不良反应发生率低于对照组，差异有统计学意义（P〈0．05）。结论甲强龙联合多索茶碱或氨茶碱均能取得较好治疗效果，但甲强龙联合多索茶碱不但疗效显著，且治疗过程中不良反应少，值得借鉴。

Objective To investigate the effect of methylprednisolone combined with doxofylline versus aminophylline in the treatment of chronic obstructive pulmonary disease in acute exacerbation period. Methods 100 patients with chronic obstructive pulmonary disease in acute exacerbation period treated at our hospital were randomly divided into an observation group and a control group, 50 cases for each group. On the basis of routine treatment, the observation group were treated with methylprednisolone and doxofylline and the control group with methylprednisolone and aminophylline. The arterial blood gas indexes were measured before and after the treatment in these two groups. The adverse reactions were observed. And the therapeutic effect was evaluated. Results There were no statistical differences in the blood gas indexes（pH, PaCO2, and PaO2） between these two groups after the treatment （P〉0.05）. The total effective rate was higher and the incidence of adverse reactions was lower in the observation group than in the control group, with statistical differences （P〈0.05）. Conclusions Methylprednisolone combined with doxofylline or aminophylline for chronic obstructive pulmonary disease in acute exacerbation period is effective, but methylprednisolone combined with doxofylline not only is effective but also has less adverse reactions in the treatment process, so it is worth for reference.