纳洛酮治疗老年多发脑梗死性痴呆的疗效观察

Naloxone for elderly patients with multi-infarct dementia

目的研究多发脑梗死性痴呆患者使用纳洛酮治疗的临床效果。方法临床纳入86例本院2013年8月至2014年8月期间收治的多发脑梗死性痴呆患者，按随机数字表法分为两组，各43例。其中43例患者使用常规治疗作为对照组，另43例患者在常规治疗基础上使用纳洛酮进行治疗作为观察组。观察两组患者脑缺血及生活质量情况等。结果治疗前，观察组Hachinski评分、ADL评分以及HDS-R评分与对照组比较差异无统计学意义，P〉0．05；治疗后观察组Hachinski评分、ADL评分以及HDS-R评分明显优于对照组，P〈0．05。结论多发脑梗死性痴呆患者采用纳洛酮进行治疗效果显著，明显改善脑缺血情况，提高患者生活质量，值得临床应用及推广。

Objective To study the clinical effect of naloxone for elderly patients with multi-infarct dementia. Methods 86 elderly patients with multi-infarct dementia treated at our hospital from August, 2013 to August, 2014 were selected and randomly divided into a control group and an observation group, 43 cases for each group. The control group were conventional treated; in addition, the observation group took naloxone. The cerebral ischemia and life quality in both groups were observed. Results The scores of Hachinski, ADL, and HDS-R of the observation group were not statistically different from those of the control group before the treatment （P〉0.05）. After the treatment, the scores of Hachinski, ADL, and HDS-R were lower in the observation group than in the control group （P〈0.05）. Conclusion Naloxone for elderly patients with multi-infarct dementia is quite effective and can greatly improve their cerebral ischemia and life quality. It is worth being clinically generalized.