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高通量测序分析1株H7N9流感病毒的全基因 被引量：3

Genome Analysis of a H7N9 Influenza Virus by High-throughput Sequencing
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摘要 为探索利用高通量测序开展H7N9亚型流感的监测、全基因分析和溯源研究的方法,使用Ion Torrent PGM测序仪对1株H7N9流感病毒进行了全基因测序,分析了此毒株的基因组特性和进化特征。结果显示,该毒株与2013年引起我国华东地区疫情的H7N9流感毒株的亲缘关系较近;纵观在不同年代和地点分离的H7N9流感病毒的6个内部基因,2013年疫情之前和之后的H7N9流感病毒存在明显差异。 To discuss the serveillance,genome analysis and source tracing of H7N9 influenza virus genome by highthroughput sequencing,the genome of a H7N9 influenza virus was sequenced by Ion Torrent PGM. The characteristics of genome and evolution were analyzed. The results showed that the virus was similar to those viruses causing the H7N9 influenza outbreaks of eastern China in 2013. Comprehensive analysis with the 6 internal genes of H7N9 influenza virus isolated from different areas and time showed that the H7N9 influenza viruses isolated after the outbreaks in 2013 were very different from those viruses isolated before.
作者 王楷宬 邱源 庄青叶 张笑春 王通 陈继明
机构地区 中国动物卫生与流行病学中心
出处 《中国动物检疫》 CAS 2016年第4期72-76,共5页 China Animal Health Inspection
基金 科技部科技基础性专项(SQ2012FY3260033) 中国动物卫生与流行病学中心创新基金(2015IF-0004FF)
关键词 H7N9流感病毒 高通量测序 基因组 分子演化 H7N9 influenza virus high-throughput sequencing genome molecular evolution
分类号 S855.3 [农业科学—临床兽医学]
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参考文献20

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二级参考文献18

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中国动物检疫
2016年 第4期

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