AMAP1蛋白在结直肠癌中的表达及临床意义

Expression of AMAP1 in colorectal cancer and its clinical significance

目的检测结直肠癌组织中Myc-binding protein-associated protein 1(AMAP1)蛋白的表达,并探讨AMAP1与结直肠癌浸润和转移的相关性。方法应用免疫组织化学法检测76例结直肠癌组织及癌旁正常组织中的AMAP1蛋白表达,并分析其与临床病理特征的关系。结果 AMAP1在结直肠癌中表达率为61.8%,与癌旁正常组织(2.6%)比较差异有统计学意义(P<0.05)。AMAP1阳性表达在肿瘤浸润深度、淋巴结转移、远处转移、脉管转移、临床分期和分化程度方面差异有统计学意义(均P<0.05),在性别、年龄方面差异无统计学意义(均P>0.05)。结论 AMAP1的表达与结直肠癌的浸润和转移密切相关。

Objective To detect Myc- binding protein- associated protein 1（ AMAP1） protein expression in colorectal cancer tissue,and investigate the relationship between AMAP1 expression and colorectal cancer invasion and metastasis. Methods Use immunohistochemistry to detect AMAP1 protein expression in 76 cases of colorectal cancer tissue,and analyze its relationship with clinical pathological factors. Results High expression of AMAP1 was found in colorectal cancer（61. 8%） compared with normal tissue（2. 6%）,with a significant difference（ P〈0. 05）. Positive expression of AMAP1 has a significant correlation with tumor depth of invasion,lymph node metastasis,distant metastasis and vascular invasion,clinical stage and differentiation degree（ P〈0. 05）,but no significant difference in comparison with gender and age（ P〉0. 05）. Conclusion The high expression of AMAP1 is associated with invasion and metastasis of colorectal cancer.