牵正散联合温针灸足三里对急性特发性面神经麻痹患者血管内皮祖细胞影响的临床观察

Effects of “Qianzheng San”with warm acupuncture at Zusanli on endothelial progenitor cells from peripheral blood in patients with acute idiopathic facial palsy

目的观察牵正散联合温针灸足三里治疗急性特发性面神经麻痹的临床疗效。方法将60例急性特发性面神经麻痹患者随机分为治疗组与对照组,每组30例。对照组予常规西药治疗,治疗组在对照组治疗基础上予牵正散联合温针灸足三里。两组疗程均为14天,观察临床疗效,比较外周血血管内皮祖细胞(EPCs)计数及EPCs集落计数的变化情况。结果 1治疗组、对照组临床痊愈率分别为86.67%和60.00%;组间临床疗效比较,差异有统计学意义,治疗组明显优于对照组(P<0.05)。2治疗前后组内比较,两组EPCs计数与EPCs集落计数均增加,差异有统计学意义(P<0.05);组间治疗后比较,EPCs计数与EPCs集落计数差异均有统计学意义(P<0.05)。结论牵正散联合温针灸足三里治疗急性特发性面神经麻痹的疗效满意,其机制可能与促进血管内皮损伤的修复有关。

Objective To observe the clinical efficacy on patient with acute facial paralysis with ＂Qianzheng San＂（ QZS） and warm acupuncture at Zusanli（ ST36）. Methods Sixty cases with acute idiopathic facial palsy were randomly divided into treatment group and control group,30 cases in each group. The control group treated with normal western medicine and the treatment group was treated with QZS and warm acupuncture of Zusanli on the basis of normal treatment.The treatment was 14 d for both groups,and the number of EPCs from peripheral blood and number of proliferative colonies of EPCs were measured and comparison was made between two groups. Results 1The marked effective rate was 86. 67% for treatment group and 60. 00% for control group,and the difference was significant（ P 0. 05）. 2 Compared in each group before and after treatment,the number of EPCs and the number of proliferative colonies of EPCs of two groups both were increased,and the difference was statistically significant（ P 0. 05）. Compared between groups after treatment,there was significant difference in the number of EPCs and the number of proliferative colonies of EPCs（ P 0. 05）. Conclusion There was significant curative effect on patient with acute facial paralysis with QZS and Warm Acupuncture Zusanli,and the mechanism may be related to promote vascular endothelial injury repair.