盐酸贝那普利片与缬沙坦影响老年急性心肌梗死患者心功能的随机对照研究

Heart Function Influence Comparison of Benazepril Hydrochloride and Valsartan in Elderly Patients with Acute Myocardial Infarction

目的比较盐酸贝那普利片与缬沙坦对老年急性心肌梗死(AMI)患者心功能改善情况的影响。方法将100例老年AMI患者按随机数字表法分为对照组与试验组,各50例。对照组患者采用缬沙坦治疗,试验组患者采用盐酸贝那普利片治疗,对比两组患者的临床疗效。结果治疗后,试验组患者总有效率为96.67%,明显高于对照组的70.00%(P<0.05);试验组患者治疗前后左室射血分数(LVEF)和B型脑利钠肽(BNP)的改善程度均明显大于对照组患者(P<0.05);试验组总胆固醇(TC)为(3.12±0.78)mmol/L,低密度脂蛋白胆固醇(LDL-C)为(1.48±0.46)mmol/L,均显著低于对照组的(3.94±0.79)mmol/L和(2.39±0.94)mmol/L(P<0.05)。结论盐酸贝那普利片与缬沙坦治疗老年AMI均有调血脂、通畅血管的功效,可显著降低心血管疾病致死及致残发生的概率,提高患者生存质量,但盐酸贝那普利效果较缬沙坦更佳。

Objective To compare the heart function improvement of benazepril hydrochloride and valsartan in the treatment of elderly patients with acute myocardial infarction.Methods 100 cases of elderly patients with acute myocardial infarction were divided into the control group and the experimental group according to the random number table method,50 cases in each group.The control group was given valsartan treatment,and the experimental group was treated with benazepril hydrochloride.The clinical efficacy was compared between the two groups.Results After treatment,the total effective rate in the experimental group was 96.67%,which was significantly higher than 70.00% in the control group（P〈0.05）;the improvement of the left ventricular ejection fraction and B-type natriuretic peptide before and after treatment in the experimental group were obviously better than the control group（P〈0.05）;TC was（3.12±0.78） mmol / L,LDL-C was（1.48±0.46） mmol / L in the experimental group,which were significantly lower than（3.94±0.79）mmol / L,（2.39±0.94） mmol / L in the control group（P〈0.05）.Conclusion Benazepril hydrochloride and valsartan can reduce lipid,unobstructed blood vessels,reduce heart vascular disease probability of disability and death significantly,improve the quality of life of patients,but the efficacy of the benazepril hydrochloride treatment is better than valsartan.