小儿肺炎支原体感染并中枢神经系统受累的临床治疗研究

Clinical research of children with mycoplasma pneumoniae complicated with central nervous system infection

目的阿奇霉素联合丙种球蛋白与阿奇霉素单药治疗肺炎支原体感染合并中枢神经系统受累的患儿临床比较。方法针对我院2012年1月至2014年3月间54例肺炎支原体感染合并中枢神经系统受累的患儿,采用完全随机分组分为观察组(阿奇霉素联合丙种球蛋白实验组)30例和对照组(阿奇霉素单药实验组)24例,观察两组治疗效果。结果观察组治疗有效率96.7%显著高于对照组75.0%,两组比较有统计学意义(P<0.05);观察组患儿发热、头痛呕吐、嗜睡、抽搐消失时间均低于对照组,两组比较有统计学意义(P<0.05);观察组平均住院时间(17±4.78)天,较对照组(22±5.91)天明显缩短,且差异均有统计学意义(P<0.05)。结论对于肺炎支原体感染并中枢神经系统受累的患儿,阿奇霉素联合丙种球蛋白治疗效果优于单用阿奇霉素。故确诊患儿应当在早期联用阿奇霉素与丙种球蛋白,改善预后。

Objective To compare and investigate the clinical efficacy of azithromycin combined with gamma globulin and azithromycin in the treatment of children with mycoplasma pneumoniae complicated with central nervous system （CNS） infection. Methods 54 children with mycoplasma pneumoniae complicated with CNS infection in our hospital from January 2012 to March 2014 were randomly divided into the observation group （ azithromycin combined with gamma globulin） and the control group （ azithromycin monotherapy）. The efficacy of the two groups was com- pared. Results The effective rate was 96. 7% in the observation group, which was significantly higher than that in the control group （75 % ） （P 〈 O. 05 ）. The disappeared time of fever, headache, vomiting, somnolence and convul- sion was significantly shorter in the observation group than in the control group （ P 〈 0. 05 ）. The average duration of hospital stay was （ 17 ＋ 4. 78 ） in the observation group and （22 ＋ 5.91 ） in the control group （ P 〈 O. 05 ）. Conclu- sion Azithromycin combined with gamma globulin is better than azithromycin monotherapy in the treatment of chil- dren with mycoplasma pneumoniae complicated with CNS infection. So the children which are confirmed should be treated with azithromycin combine with gamma globulin as soon as possible, in order to improve their prognosis.