慢性阻塞性肺疾病患者海马氢质子磁共振波谱分析研究

Analysis and Research of Proton Magnetic Resonance Spectroscopy in Hippocampus in Patients with Chronic Obstructive Pulmonary

目的研究慢性阻塞性肺疾病(COPD)患者海马氢质子磁共振波谱(1H-MRS)的特点。方法随机选取2012年2月—2015年1月期间收治的32例COPD患者和30例健康志愿者分别纳入研究组和对照组。采用1H-MRS检测双侧海马的N-乙酰基天门冬氨酸(NAA)、胆碱复合物(Cho)和肌酸复合物(Cr)。结果研究组左右侧海马NAA/Cr值((1.12±0.37)和(1.16±0.41))均显著低于对照组((1.63±0.40)和(1.69±0.43)),差异具有统计学意义(t=4.963、P=0.007和t=4.856、P=0.023);研究组左右侧海马Cho/Cr值((1.67±0.36)和(1.62±0.40))均显著高于对照组((1.39±0.41)和(1.31±0.39)),差异具有统计学意义(t=3.469、P=0.013和t=3.019、P=0.047)。结论慢性阻塞性肺疾病患者存在海马神经元的代谢异常。

Objective To research the characteristics of proton magnetic resonance spectroscopy in hippocampus（1H-MRS）in patients with chronic obstructive pulmonary（COPD）. Methods 32 cases of COPD patients treated from February2012 to January 2015 were randomly selected as the research group and 30 cases of healthy volunteers treated at the same period were selected as the control group, the N- acetyl aspartate（NAA）, choline-containing compounds（Cho）. Results In the bilateral hippocampus, the NAA/Cr ratio in patients with COPD（（1.12±0.37）and（1.16±0.41）） lower than that in normal controls（（1.63±0.40）and（1.69±0.43））, the difference was statistically significant（t=4.963、P=0.007 and t=4.856/P=0.023）.the Cho/Cr ratio in patients with COPD（（1.67±0.36）and（1.62±0.40）） showed Higher than that in normal controls（（1.39±0.41） and（1.31±0.39））, the difference was statistically significant（t=3.469/P=0.013 and t=3.019/P=0.047）. Conclusion Patients with chronic obstructive pulmonary have metabolism of hippocampal neurons abnormities.