还原性谷胱甘肽与复方甘草酸苷注射液的疗效及经济学评价

Curative Effect and Economic Evaluation of Reduced Glutathione and Compound Glycyrrhizin Injection

目的探究还原性谷胱甘肽与复方甘草酸苷注射液的疗效及经济学价值对比。方法回顾性分析2013年1月—2015年1月该院182化疗药物引发的肝损害患者资料,根据用药不同进行分组,其中应用还原性谷胱甘肽治疗96例,设为A组,应用复方甘草酸苷注射液治疗86例,设为B组,对比两组患者的临床疗效及经济学评价。结果 A组和B组的治疗总有效率分别为91.7%和86.1%,成本分别为(798.3±43.9)元和(859.9±55.7)元,价效比为(870.8±41.6)和(999.3±66.9),A组成效比明显优于B组,差异有统计学意义(P<0.05)。结论还原性谷胱甘肽治疗化疗药物相关性肝损害的疗效好,成本低,相对于复方甘草酸苷注射液的应用价值更大,值得在临床上推广和应用。

Objective To discuss the effect and economic value comparison of reduced glutathione and compound glycyrrhizin injection. Methods The clinical data of 182 cases of patients with liver lesion caused by chemotherapeutics treated in our hospital from January 2013 to January 2015 were retrospectively analyzed and divided into two groups according to the different drug uses, the group A（n=96） were treated with reduced glutathione, the group B（n=86） were treated with compound glycyrrhizin injection, the clinical curative effect and economic evaluation of the two groups were compared. Results The total effective rate, cost and price efficiency ratio in the group A and the group B were respectively 91.7% and86.1%,（798.3±43.9）yuan and（859.9±55.7）yuan,（870.8±41.6） and（999.3±66.9）, the effect ratio in the group A was obviously better than that in the group B, the difference was statistically significant（P0.05）. Conclusion Reduced glutathione in treatment of liver lesion induced by chemotherapeutic drugs has a good curative effect and a low cost, and the application value of it is bigger compared with that of compound glycyrrhizin injection, which is worthy of promotion and application in clinic.