拜阿司匹林联合氯吡格雷治疗进展型脑梗死的临床效果

Clinical Effect of Bayaspirin Combined with Clopidogrel in the Treatment of Progressive Cerebral Infarction

目的:探讨拜阿司匹林联合氯吡格雷治疗进展型脑梗死的效果及安全性。方法:选取2012年5月-2015年5月笔者所在医院收治的进展型脑梗死患者112例,随机分为对照组(n=56)和治疗组(n=56),对照组口服拜阿司匹林治疗,100 mg/次,每晚1次,治疗组在对照组的基础上口服氯吡格雷治疗,75 mg/次,1次/d。比较两组患者的临床疗效、神经功能缺损程度评分和凝血功能的变化情况。结果:治疗组的总有效率明显高于对照组,并且神经功能恢复明显优于对照组,差异均有统计学意义(P<0.05),而两组的凝血功能变化比较,差异无统计学意义(P>0.05)。结论:拜阿司匹林联合氯吡格雷治疗进展型脑梗死的临床效果确切,可延缓病情的进展,改善患者的神经功能。

Objective：To investigate the clinical efficacy and safety of Bayaspirin combined with Clopidogrel in the treatment of progressive cerebral infarction.Method：112 patients with progressive cerebral infarction from May 2012 to May 2015 in our hospital were selected,they were randomly divided into the treatment group（n=56）and the control group（n=56）.The control group was treated with Bayaspirin,each time 100 mg,once every night,the treatment group was treated with Clopidogrel on the basis of the control group,each time 75 mg,once a day.The clinical efficacy,neural function deficit score and the change of blood coagulation function between two groups were compared.Result：The total effective rate of the treatment group was significantly higher than that of the control group,and the neural functional improvement was obviously better than the control group,the differences were statistically significant（P〈0.05）,however,there were no statistically significant differences in the changes of coagulation function between the two groups（P〈0.05）.Conclusion：The clinical effect of Bayaspirin combined with Clopidogrel in the treatment of progressive cerebral infarction is exact,which can delay the progression of the disease and improve the neurological function of the patients.