CA125与HE4联合检测在子宫内膜癌诊断中的价值

Clinical value of combined detection of CA125 and HE4 in diagnosis of endometrial carcinoma

目的:探讨CA125与HE4联合检测在子宫内膜癌诊断中的价值。方法:分别检测20例正常子宫内膜者、41例子宫内膜不典型增生患者、38例子宫内膜癌患者的血清CA125与HE4水平,并对结果进行统计学分析。结果:子宫内膜癌患者中血清HE4及CA125水平均明显高于子宫内膜不典型增生组和对照组,差异有统计学意义(P<0.05);晚期子宫内膜癌患者血清CA125、HE4水平均明显高于早期患者,差异有统计学意义(P<0.05);HE4与CA125诊断子宫内膜癌敏感性相当(39.47%VS 34.21%),差异无统计学意义(P>0.05),但联合检测敏感性为57.89%,较单项检测均有提高,差异有统计学意义(P<0.05),但是血清HE4比联合检测具有更高的特异性(P<0.05),其阳性预测值显著高于CA125(P<0.05)。结论:血清HE4对子宫内膜癌诊断具有较好的特异性,但联合检测CA125与HE4可提高诊断的敏感性。

Objective：To investigate the clinical value of combined detection of CA125 and HE4 in diagnosis of endometrial carcinoma.Methods：The serum CA125 and HE4 levels 20 cases with normal endometrium 41 cases of endometrial atypical hyperplasia,38 cases of endometrial cancer in patients were detected,and the results were statistically analyzed. Results ：The serum HE4 and CA125 levels in patients with endometrial cancer were significantly higher than the atypical endometrial hyperplasia group and the control group,the difference was of statistically significant（P0.05）; and that in advanced endometrial cancer were significantly higher than patients in early stage,the difference was of statistically significant（P0.05）; The sensitivity in HE4 and CA125 of endometrial cancer were about the same（39.47% VS 34.21%）,the difference was not of statistically significant（P 0.05）,but the joint detection sensitivity was57.89%,were increased than the single test,the difference was of statistically significant（P0.05）,but the serum HE4 was of a higher specificity than the combined detection（P0.05）,and the positive predictive value was significantly higher than CA125（P 0.05）.Conclusion：The serum HE4 in the diagnosis of endometrial carcinoma has good specificity,but the combined detectionof CA125 and HE4 can improve the diagnostic sensitivity.