黑色素瘤缺乏因子2炎性体在抗微生物感染中的研究进展

Research progress on absent in melanoma 2 in defending pathogenic microorganism invasion

固有免疫是机体抵抗病原微生物入侵的第一道防线。黑色素瘤缺乏因子2（ Absent in melanoma 2，AIM2）作为DNA感受器，是固有免疫系统非常重要的一员，它识别病原微生物双链DNA形成AIM2炎性体，激活Caspase-1依赖的细胞焦亡且促进IL-18和IL-1β的成熟与释放，有助于宿主抑制和清除病原微生物。 AIM2炎性体在抵抗李斯特菌、土拉弗朗西斯菌、肺炎链球菌、结核分枝杆菌、烟曲霉、牛痘病毒、小鼠巨细胞病毒及乙型肝炎病毒等感染中发挥重要作用。该文就AIM2炎性体各组分构成及其在抗微生物感染中的作用进行综述。

Innate immunity is on the frontline of fight against pathogenic microorganism invasion .As a DNA sensor, absent in melanoma 2 （AIM2） is an important member of innate immune system.It can recognize dsDNA of pathogenic microbes to form AIM 2 inflammasomes , which facilitates defending and clearing the invasion of pathogens by activating caspase-1 dependent pyroptosis and the mature of IL-18 and IL-1β.AIM2 inflammasomes play an important part in responding to Listeria monocytogenes, Francisella tularensis, Streptococcus pneumoniae, Mycobacterium tuberculosis, Aspergillus fumigatus, vaccinia virus , murine cytomegalovirus , and hepatitis B virus infections .This paper introduces the components of AIM 2 inflammasomes and summarizes its function in defending the invasion of pathogenic microorganisms .