门冬氨酸钾镁治疗急性心梗心律失常的疗效与安全性

Curative Effect and Security of Potassium Magnessium Aspartape in Treatment of Acute Myocardial Infarction Arrhythmia

目的研究门冬氨酸钾镁治疗急性心梗心律失常患者的疗效与安全性。方法整群选取2009年9月—2013年9月间在该科经确诊的急性心梗心律失常的患者102例,经随机数字法分为观察组(51例)和对照组(51例),其中对照组病人采用常规的治疗方法,观察组在常规治疗方案基础上加用门冬氨酸钾镁治疗。结果治疗前,观察组血清钾、镁浓度分别为(3.25±0.61)mmol/L、(0.75±0.13)mmol/L,对照组分别为(3.31±0.59)mmol/L、(0.76±0.15)mmol/L,对比差异无统计学意义(P>0.05);治疗后发现观察组血清钾、血清镁分别为(4.45±0.26)mmol/L、(1.15±0.22)mmol/L,明显高于对照组的(3.82±0.53)mmol/L、(0.89±0.18)mmol/L,差异有统计学意义(P<0.05)。两组病人的不良反应发生率比较,观察组心律失常、死亡的发生率分别为22%、6%;而对照组分别为55%、25%,观察组安全性更高(P<0.05)。结论对急性心梗心律失常病人常规使用门冬氨酸钾镁,能够明显提高其血清钾镁浓度,不良反应发生率低,安全性高,因此值得在临床中推广使用。

Objective To research the curative effect and security of potassium magnessium aspartape in treatment of acute myocardial infarction arrhythmia. Methods 102 cases of patients with acute myocardial infarction arrhythmia diagnosed in our department from September 2009 to September 2013 were selected and randomly divided into two groups with 51 cases in each, the control group received routine treatment method, the observation group received additional potassium magnessium aspartape treatment on the basis of the control group. Results Before treatment, the concentration of serum potassium and serum magnesium was respectively（3.25±0.61）mmol/L and（0.75±0.13）mmol/L in the observation group and（3.31±0.59）mmol/L and（0.76±0.15）mmol/L in the control group, and the difference was not obvious between groups, after treatment, the concentration of serum potassium and serum magnesium was respectively（4.45±0.26）mmol/L and（1.15±0.22）mmol/L, which was obviously higher than that in the control group,（（3.82±0.53）mmol/L,（0.89±0.18）mmol/L）, and the difference was obvious（P〈0.05）, the incidences of arrhythmia and death were respectively 22% and 6% in the observation group and 55% and 25% in the control group, the security was higher in the observation group（P〈0.05）. Conclusion Potassium magnessium aspartape in treatment of patients with acute myocardial infarction arrhythmia routinely can obviously improve the concentration of serum potassium and serum magnesium with low incidence of adverse reactions and high security, which is worthy of promotion and application in clinic.