持续热灌注腹腔化疗在胃肠肿瘤治疗中的效果分析

Effect Analysis of Sustained Thermal Perfusion Intraperitoneal Chemotherapy in Treatment of Gastrointestinal Tumors

目的研究持续热灌注腹腔化疗联合静脉化疗治疗进展期胃肠肿瘤的临床效果。方法整群选取该院2014年6月—2015年6月同住院转移性胃癌患者64例为研究对象,随机分为对照组与观察组,每组32例,其中对照组采用采取常规腹腔化疗联合静脉化疗,观察组采用热灌注腹腔化疗联合静脉化疗。对两组患者化疗效果及并发症等进行对比分析,评价其疗效。结果观察组的治疗总有效率68.75%高于对照组的40.63%,差异具有统计学意义(P<0.05)。观察组和对照组不良反应发生率分别87.5%、90.6%,差异无统计学意义(P>0.05)。结论该方法有效的对肿瘤组织或细胞起到抑制作用,提高患者的生活质量。

Objective To research the clinical effect of sustained thermal perfusion intraperitoneal chemotherapy combined with venous chemotherapy in treatment of gastrointestinal tumors at progressive stage. Methods 64 cases of patients with metastatic gastrointestinal tumors from June 2014 to June 2015 were selected as the research object and randomly divided into two groups with 32 cases in each, the control group were treated with routine intraperitoneal chemotherapy combined with venous chemotherapy, the observation group were treated with thermal perfusion intraperitoneal chemotherapy combined with venous chemotherapy, the chemotherapy effects and complications of the two groups were compared and analyzed, and the curative effects were evaluated. Results The total effective rate in the observation group was higher than that in the control group,（68.75% vs 40.63%）and the difference was statistically significant（P〈0.05）,the difference in the incidence of adverse reaction between the observation group and control group was not statistically significant（87.5% vs90.6%）（P〉0.05）. Conclusion The method can effectively restrain tumor tissues or cells and improve the patient＇s quality of life.