血清中HCY与子宫动脉螺旋小动脉血流变化对胎盘早剥的早期诊断

Early Diagnosis of HCY in Serum and Changes of Blood Flow in the Spiral Small Artery of Uterine Artery for Placental Abruption

目的研究血清中同型半胱氨酸(HCY)、子宫螺旋小动脉血液动力学指标的变化对胎盘早剥早期诊断的临床意义。方法选取2011年12月—2014年12月期间被长春市妇产医院初诊诊断为子痫前期孕妇72例,其中子痫前期孕妇并发胎盘早剥30例为试验组,子痫前期孕妇无胎盘早剥的42例作为对照组。测定孕妇血清中HCY的含量及子宫螺旋动脉血流动力学参数:PI、RI、S/D。结果试验组的血清HCY含量明显高于对照组,差异有统计学意义(P<0.05);试验组子宫胎盘螺旋小动脉S/D,PI,RI值明显高于对照组,差异有统计学意义(P<0.05);试验组血清中HCY值与子宫螺旋小动脉PI、RI、S/D值呈正相关。结论子宫胎盘螺旋小动脉血流动力学系数、血清中HCY检测值对子痫前期孕妇胎盘早剥预测及早期诊断有一定临床价值。

Objective To research the clinical significance of the early diagnosis of homocysteine in serum and changes of hemodynamic indexes in the uterine spiral small artery for placental abruption. Methods 72 cases of women with preeclampsia diagnosed by Changchun Obstetrics and Gynecology Hospital at the first visit from December 2011 to December 2014 were selected, 30 cases of women with preeclampsia complicated by placental abruption were regarded as the experimental group, 42 cases of women with preeclampsia without placental abruption were regarded as the control group, the content of HCY in serum and parameters of uterine spiral artery hemodynamics（PI,RI and S/D） were measured.Results The content of HCY in serum in the experimental group was obviously higher than that in the control group, the difference was obvious with statistically significant（P〈0.05）,the S/D,PI and RI values of uterine placental spiral small artery in the experimental group were obviously higher than those in the control group, the differences were obvious with statistically significant（P〈0.05）, in the experimental group, the HCY value was positively correlated with the PI,RI and S/D values of the uterine spiral small artery. Conclusion The uterine placental spiral small artery hemodynamics coefficients and HCY detection values in serum have a certain value for the prediction and early diagnosis of placental abruption of women with preeclampsia.