新辅助化疗结合腹腔镜手术治疗结直肠癌40例分析

Analysis of Neoadjuvant Chemotherapy Combined with Laparoscopic Operation in Treatment of 40 Cases with Colorectal Cancer

目的分析40例结直肠癌患者行新辅助化疗结合腹腔镜手术治疗的临床疗效,并做合理评价。方法研究对象为整群选取2012年1月—2013年1月该院收治的结直肠癌患者69例,随机分组,观察组:采取新辅助化疗结合腹腔镜手术的治疗方案;对照组:采取腹腔镜手术治疗方案。分别比较两组患者手术的具体情况、术后的临床疗效及并发症的发生率;并随访2年统计患者的存活率,对两组治疗方案的优缺点进行综合评价。结果经比较,观察组术中需切除的淋巴结数目、手术的时间、住院观察期等相关指标均优于对照组,P﹤0.05;术后并发症发生率差异无统计学意义,P>0.05;且随访统计数据显示:观察组患者当前存活28例(70.0%)、KPS评分(72.12±9.23)分,对照组12例(41.4%)、KPS评分(60.19±9.56)分,P<0.05。结论结直肠癌患者经新辅助化疗后,腹腔镜手术的操作难度显著降低且预后治疗效果好,有效提高了患者的存活率及机体功能恢复力,可作为治疗方案的首选。

Objective To analyze the clinical curative effect of neoadjuvant chemotherapy combined with laparoscopic operation in treatment of 40 cases with colorectal cancer and to make a reasonable evaluation. Methods 69 cases of patients with colorectal cancer treated from January 2012 to January 2013 were selected as the research object and randomly divided into two groups, the observation group were treated with neoadjuvant chemotherapy combined with laparoscopic operation,the control group were treated with laparoscopic operation, the specific condition of operation, postoperative clinical curative effect and incidence of complications of the two patients were respectively compared. Results After comparison, the correlative indicators such as number of lymph nodes needing to be removed in operation, operation time and observation period in hospital in the observation group were better than those in the control group, P ﹤ 0.05, there was no obvious difference in the incidence of postoperative complications P0.05, the follow-up statistical data showed that 28 cases were currently survival（70.0%）, KPS score was（72.12±9.23）points in the observation group, 12 cases were currently survival（41.4%）and KPS score was（60.19±9.56）points, P0.05. Conclusion After neoadjuvant chemotherapy for patients with colorectal cancer,the operative difficulty index of laparoscopic operation is obviously decreased and the prognosis treatment effect is good,and it effectively increases the patient＇s survival rate and body function recovery force and can be used as the preferable treatment plan.