56例新生儿肺动脉高压运用西地那非治疗的疗效和安全性初探

Study on Curative Effect and Security of Sildenafil in Treatment of 56 Cases with Neonatal Pulmonary Hypertension

目的研究分析西地那非治疗新生儿肺动脉高压的临床效果及其安全性。方法整群选取2013年2月—2015年2月该院收治的新生儿肺动脉高压患儿112例,随机分为两组,各56例。对照组采用常规治疗,观察组采用西地那非治疗,对比两组治疗前后动脉血气和肺动脉压变化。结果观察组治疗后OI、PAP指标分别为(8.0±4.1)、(25.2±7.4)mm Hg,显著低于对照组,差异有统计学意义(P<0.01);观察组治疗后Pa O_2指标为(74.7±9.1)mm Hg,显著高于对照组,差异有统计学意义(P<0.01)。结论西地那非治疗新生儿肺动脉高压效果显著,能够有效降低动脉氧合指数和肺动脉压,提高氧分压,值得推广。

Objective To research and analyze the clinical effect and its security of sildenafil in treatment of neonatal pulmonary hypertension. Methods 112 cases of children with neonatal pulmonary hypertension admitted and treated in our hospital from February 2013 to February 2015 were selected and randomly divided into two groups with 56 cases in each, the control group were treated with conventional method, the observation group were treated with sildenafil, the changes of arterial blood gas and pulmonary artery pressure of the two groups were compared. Results The indexes such as OI and PAP after treatment were respectively（8.0±4.1）mm Hg and（25.2±7.4）mm Hg, which were obviously lower than those in the control group, and the differences were statistically significant（P0.01）, the Pa O2 after treatment was（74.7±9.1）mm Hg in the observation group, which was obviously higher than that in the control group, and the difference was statistically significant（P〈0.01）. Conclusion The effect of sildenafil in treatment of neonatal pulmonary hypertension is obvious, and it can effectively reduce the arterial oxygenation index and pulmonary artery pressure and is worth promotion.