口服左旋肉碱与卵胞浆内单精子注射治疗男性严重少、弱精子症的临床探讨

Clinical Observation on the Treatment of Male Patients with Severe Oligospermia and Asthenospermia by Oral Administration of L-carnitine and Intracytoplasmic Sperm Injection

目的 探讨口服左旋肉碱与卵胞浆内单精子注射治疗男性严重少、弱精子症的临床疗效。方法整群选取2012年2月—2014年5月在医院收治的72例男性不育症的患者,将其作为临床研究对象,采用随机的方式分为实验组36例和对照组36例,实验组实行ICSI治疗前,前3个月男方服用口服左旋肉碱,对照组不服用左旋肉碱。对治疗后两组受精率、优质胚胎率、临床妊娠率进行分析。结果经统计分析,实验组的受精率29(80.55%)、优质胚胎率17(47.22%)、临床妊娠率12(33.33%)均比对照组21(58.33%)、9(25.00%)、9(25.00%)的高,差异有统计意义(P<0.05)。结论口服左旋肉碱与卵胞浆内单精子注射可明显提高男性精子的受精率与临床妊娠率,可以选择性作为临床辅助治疗男性不育症,值得临床推广应用。

Objective To investigate the clinical effect of oral administration of L-carnitine and intracytoplasmic sperm injection（ICSI） in the treatment of male patients with severe oligospermia and asthenospermia. Methods 72 males with infertility admitted in a hospital from February 2012 to May 2014 were selected as the clinical subjects and randomly divided into the experimental group and control group with 36 cases in each. Three months before the ICSI, the experimental group took L-carnitine orally, while the control group did not. The fertility rate, high-quality embryo rate and clinical pregnancy rate of the two groups were analyzed after treatment. Results The result of statistical analysis showed that the fertilization rate was much higher in the experimental group than in the control group [29（80.55%） vs 21（58.33%）], P〈0.05; the highquality embryo rate was also significantly higher in the experimental group than in the control group[17（47.22%） vs 9（25.00%）],P0.05; the clinical pregnancy rate was obviously higher in the experimental group than in the control group [12（33.33%） vs9（25.00%）], P0.05. Conclusion Oral administration of L-carnitine and ICSI can significantly improve the fertility rate and clinical pregnancy rate, which can be selected as an adjunctive therapy for the males with infertility. And it is worthy of clinical application and promotion.