甲氨蝶呤联合米非司酮治疗宫外孕临床疗效分析

Clinical Curative Effect Analysis of Methotrexate Combined with Mifepristone in Treatment of Extrauterine Pregnancy

目的研究和探索采用甲氨蝶呤联合米非司酮保守治疗宫外孕的临床效果。方法随机选择该院从2012年6月—2015年7月间收治的80例宫外孕患者,并随机将其分为观察组40例和对照组40例。临床中对照组只单纯运用米非司酮治疗,观察组则在运用米非司酮治疗的同时加用甲氨蝶呤联合治疗,对两组患者的临床疗效分析观察。结果通过两组患者临床疗效比较研究和分析,观察组和对照组的治疗总有效率分别为92.5%和72.5%,两组的总有效率差异统计学意义(P<0.05)。而且在治疗过程中两组患者皆没有显著不良反应出现。结论甲氨蝶呤与米非司酮联合保守治疗宫外孕,治愈率高且较少不良反应,临床疗效显著,具有良好的临床推广和应用价值。

Objective To research and explore the clinical effect of methotrexate combined with mifepristone in conservative treatment of extrauterine pregnancy. Methods 80 cases of patients with extrauterine pregnancy treated in our hospital from June 2012 to July 2015 were selected and randomly divided into two groups with 40 cases in each, in clinic, the control group were treated with simple mifepristone, the observation group were treated with mifepristone combined with methotrexate, the clinical curative effect of the two groups was analyzed and observed. Results The clinical curative effect comparison showed that the difference in the total effective rate between the observation group and the control group was obvious with statistically significance,（92.5% vs 72.5%）（P〈0.05）, and there was no obvious adverse reaction in the two groups during treatment. Conclusion Methotrexate combined with mifepristone in conservative treatment of extrauterine pregnancy has a higher cure rate, fewer adverse reactions and an obvious clinical curative effect, which is of good clinical promotion and application value.