不同剂量米非司酮治疗子宫肌瘤的临床探讨

Clinical Observation on Different Doses of Mifepristone in Treatment of Fibroid

目的 探讨不同剂量米非司酮治疗子宫肌瘤的临床疗效。方法采用随机平行对照方法 ,随机选取2014年6月—2015年6月期间在该院住院治疗的子宫肌瘤患者100例,分为小剂量组和大剂量组两组,每组50例研究对象。小剂量组患者给予小剂量米非司酮进行治疗,大剂量组患者给予大剂量米非司酮进行治疗。结果小剂量组患者治疗后子宫体积和子宫肌瘤体积显著小于大剂量组,P<0.05组间比较差异具有统计学意义。结论应用小剂量米非司酮治疗子宫肌瘤与应用大剂量米非司酮相比,能够显著促使患者子宫体积和子宫肌瘤体积缩小,并显著改善患者的各项激素水平,且由于用药量减少,治疗过程中的不良反应更少。

Objective To observe the clinical curative effect of different doses of mifepristone in treatment of fibroid.Methods 100 cases of inpatients with fibroid treated in our hospital from June 2014 to June 2015 were randomly selected and divided into two groups with 50 cases in each, the small-dose group were treated with small-dose mifepristone, and the large-dose group were treated with large-dose mifepristone. Results The uterine volume and fibroid volume in the smalldose group were obviously bigger than those in the large-dose group, P〈0.05, the difference between groups was statistically significant by comparison. Conclusion Compared with large-dose mifepristone, small-dose mifepristone can obviously promote the reduction of the patient＇s uterine volume and fibroid volume and obviously improve the patient＇s various hormone levels, and the adverse reaction is less in the treatment process due to the reduction of dosage.