血清肌钙蛋白T、心肌酶及白介素-6联合检测对慢性心衰患者的价值

The Value of Joint Examination of Serum cTnT, Cardiac Enzymes and IL-6 to Patients with Chronic Heart Failure

目的探讨血清肌钙蛋白T、心肌酶及白介素-6联合检测对慢性心衰患者的价值。方法随机选取2014年6月—2015年5月浙江大学医学院附属第一医院收治的67例慢性心衰患者作为观察组,62例体检健康者作为对照组。对比两组及不同程度慢性心衰患者的血清肌钙蛋白T、肌酸激酶、肌酸激酶同工酶及白介素-6水平。结果观察组患者的血清肌钙蛋白T、肌酸激酶、肌酸激酶同工酶及白介素-6水平分别为(0.68±0.19)ng/m L、(118.76±23.52)U/L、(29.63±8.15)U/L及(16.81±3.56)ng/L,均明显高于对照组的(0.12±0.07)ng/m L、(56.97±16.82)U/L、(20.17±7.39)U/L及(6.85±1.68)ng/L(P<0.01);心功能Ⅳ级患者的血清肌钙蛋白T、肌酸激酶、肌酸激酶同工酶及白介素-6水平分别为(0.75±0.25)ng/m L、(122.31±28.71)U/L、(33.46±10.38)U/L及(18.53±4.28)ng/L,均显著高于心功能Ⅲ级患者的(0.59±0.13)ng/m L、(99.63±18.19)U/L、(26.16±6.27 U/L及(15.78±2.15)ng/L(P<0.05)。结论慢性心衰患者的血清肌钙蛋白T、心肌酶及白介素-6水平均呈明显增高的趋势,它们的联合检测对心功能损伤程度具有较好的提示作用。

Objective To discuss the value of joint examination of serum cTnT, cardiac enzymes and IL-6 to patients with chronic heart failure. Methods In June 2014- May 2015, 67 cases with chronic heart failure treated in the First Affiliated Hospital of Zhejiang University were observed as the observation group, 62 healthy persons were observed as the control group. The serum cTnT level, the CK level, the CK-MB level and the IL-6 level were compared between the two groups and the patients with varying degrees of chronic heart failure. Results The serum cTnT level, the CK level, the CK-MB level and the IL-6 level in the observation group patients respectively were（0.68±0.19）ng/m L,（118.76±23.52）U/L,（29.63±8.15）U/L and（16.81±3.56）ng/L, they were obviously higher than（0.12±0.07）ng/m L,（56.97±16.82）U/L,（20.17±7.39）U/L and（6.85±1.68）ng/L in the control group（P〈0.01）. The cTnT level, the CK level, the CK-MB level and the IL-6 level in the patients with heart function grade Ⅳ severally were（0.75±0.25）ng/m L,（122.31±28.71）U/L,（33.46±10.38）U/L and（18.53 ±4.28）ng/L, they were dramatically higher than（0.59 ±0.13）ng/m L,（99.63 ±18.19）U/L,（26.16 ±6.27）U/L and（15.78 ±2.15）ng/L of patients with heart function grade Ⅲ（P〈0.05）. Conclusion The serum cTnT level, the cardiac enzymes level and the IL-6 level of patients with chronic heart failure show a significant increasing trend. The joint examination of serum cTnT, cardiac enzymes and IL-6 has a good prompt action to the degree of heart function damage.