小儿肾脏疾病与脂质代谢紊乱临床探讨

Clinical Observation on Relationship between Renal Diseases in Children and Lipid Metabolism Disorder

目的探讨小儿肾脏疾病与脂质代谢紊乱的关系。方法整群选取该院2014年8月—2015年9月肾病综合征患儿为观察组,选取同期正常的健康体检小儿为对照组。检测血清TC、TG、HDL-C、LDL-C、Apo A1与Apo B。结果观察组的TC为(10.42±3.68)、TG为(2.43±2.31)、HDL-C为(2.01±2.34)、LDL-C为(7.58±2.71)以及Apo B为(1.32±0.36),均高于对照组,组间比较有差异(P<0.05)。结论小儿肾脏疾病与脂质代谢紊乱之间存在密切的关系,脂质代谢紊乱是促肾小球硬化的一个高危因素,会造成患儿的肾功能出现进行性损害。

Objective To discuss the relationship between renal diseases in children and lipid metabolism disorder. Methods The children with nephrotic syndrome treated in our hospital from August 2014 to September 2015 were selected as the observation group, the normal children with healthy physical examination at the same period were selected as the control group, and the serum TC, TG, HDL-C, LDL-C, Apo A1 and Apo B were detected. Results The TC, TG, HDL-C, LDL-C and Apo B were respectively（10.42±3.68）,（2.43±2.31）,（2.01±2.34）,（7.58±2.71） and（1.32±0.36）, which were higher than those in the control group, and there were differences between groups by comparison（P〈0.05）. Conclusion The renal diseases in children have a close relationship with lipid metabolism disorder, the lipid metabolism disorder is a high risk factor of glomerulosclerosis, and it can lead to progressive damage of the children＇s renal function.